Drug Class Detail

Drug Class Antimicrotubule Agent


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Paclitaxel Taxol 7-Epipaclitaxel Antimicrotubule Agent 11 BCL2 Family Inhibitor 6 Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).
Docetaxel Taxotere Docetaxel anhydrous|Docefrez Antimicrotubule Agent 11 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (NCI Drug Dictionary).
Crolibulin microtubulin inhibitor EPC2407|EPC2407 Antimicrotubule Agent 11 Crolibulin (EPC2407) is a small molecule that binds to and prevents tubulin polymerization, which may cause cell cycle arrest, apoptosis and decreased cell proliferation (NCI Drug Dictionary).
Plinabulin NPI-2358 Antimicrotubule Agent 11 Plinabulin is a diketopiperazine derivative that disrupts microtubule organization, leading to cell cycle arrest in tumor cells and collapse of tumor vasculature (PMID: 16317287).
Cabazitaxel Jevtana XRP6258|RPR-116258A Antimicrotubule Agent 11 Jevtana (cabazitaxel) inhibits microtubule depolymerization by binding to tubulin, resulting in cell cycle arrest and decreased tumor cell proliferation (NCI Drug Dictionary).
ST-11 Antimicrotubule Agent 11 ST-11 targets tubulin to destabilize microtubules, and is capable of crossing the blood-brain barrier, potentially resulting increased death of tumor cells (PMID: 27325686).
Triolimus Antimicrotubule Agent 11 HSP90 Inhibitor 35 mTORC1 Inhibitor 8 Triolimus is a composed of a micelle containing the drugs rapamycin, 17-AAG, and paclitaxel, which act synergistically to inhibit tumor growth (PMID: 22896668).
ABT-751 E7010 Antimicrotubule Agent 11 ABT-751 is an anti-mitotic agent that binds to tubulin and exhibits anti-cancer activity in preclinical models (PMID: 19398903, PMID: 23670235).
BAL101553 Antimicrotubule Agent 11 BAL101553 is the prodrug of the microtubule inhibiting drug BAL27862, which may result in decreased growth and migration of tumor cells (PMID: 27540016).
Vinorelbine Navelbine Vinorelbin Antimicrotubule Agent 11 Navelbine (vinorelbine) is a tubulin binding alkaloid that inhibits tubulin polymerization, thus inhibiting spindle formation, leading to apoptosis (NCI Drug Dictionary). Navelbine (vinorelbine) is approved for use in NSCLC (FDA.gov).
Eribulin Halaven Antimicrotubule Agent 11
Molecular Profile Protein Effect Treatment Approaches