Gene Detail
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| Gene Symbol | SH2B3 | ||||||||||
| Synonyms | IDDM20 | LNK | ||||||||||
| Gene Description | SH2B3 (LNK), SH2B adapter protein 3, is an adaptor protein that integrates signaling molecules to JAK and RTK pathways and thereby negatively regulating hematopoiesis and endothelial cell physiology (PMID: 21723852). Loss of functional SH2B3 (LNK) has been associated with acute lymphoblastic leukemia (PMID: 23908464, PMID: 30103202), B-cell precursor acute lymphoblastic leukaemia (PMID: 30816328), and myeloproliferative neoplasms (PMID: 26522763), while SH2B3 (LNK) overexpression has been observed in ovarian cancer (PMID: 24704825). | ||||||||||
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