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|Synonyms||IDDM20 | LNK|
|Gene Description||SH2B3 (LNK), SH2B adapter protein 3, is an adaptor protein that integrates signaling molecules to JAK and RTK pathways and thereby negatively regulating hematopoiesis and endothelial cell physiology (PMID: 21723852). Loss of functional SH2B3 (LNK) is associated with ALL (PMID: 23908464) and MPN (PMID: 26522763) while SH2B3 (LNK) overexpression is associated with ovarian cancer (PMID: 24704825).|