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|Synonyms||CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | p21CIP1 | SDI1 | WAF1|
|Gene Description||CDKN1A, cyclin dependent kinase inhibitor 1A, also known as p21, is activated by Tp53 and may be the mediator of Tp53 inhibition of cell proliferation and induction of apoptosis (PMID: 10090408) and functions in the DNA damage response (PMID: 20096807). Loss of Cdkn1a may enable cell proliferation and migration in gastric (PMID: 29602637), liver (PMID: 29408622), bladder (PMID: 29602637), and osteosarcoma cancers (PMID: 29115549) and decreased expression in chromophobe renal cell carcinoma is associated with decreased survival (PMID: 32079343).|