Gene Detail

Gene Symbol CDKN1A
Synonyms CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | p21CIP1 | SDI1 | WAF1
Gene Description CDKN1A, cyclin-dependent kinase inhibitor 1, also known as p21, is activated by Tp53 and may be the mediator of Tp53 inhibition of cell proliferation and induction of apoptosis (PMID: 10090408) and functions in the DNA damage response (PMID: 20096807). Loss of Cdkn1a may enable cell proliferation and migration in gastric (PMID: 29602637), liver (PMID: 29408622), bladder (PMID: 29602637), and osteosarcoma cancers (PMID: 29115549).
Entrez Id 1026
Chromosome 6
Map Location 6p21.2
Canonical Transcript NM_001220777

Additional content available in CKB BOOST