Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol IKZF1
Synonyms CVID13 | Hs.54452 | IK1 | IKAROS | LyF-1 | LYF1 | PPP1R92 | PRO0758 | ZNFN1A1
Gene Description IKZF1, IKAROS family zinc finger 1, is a zinc finger transcription factor that regulates hematopoietic differentiation and immune system development, and functions as a tumor suppressor (PMID: 24659638, PMID: 22150303). Mutations in IKZF1 are associated with acute lymphoblastic leukemia (PMID: 24659638, PMID: 22150303) and IKZF1 deletions have been observed in pediatric precursor B-cell ALL (PMID: 31076445).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
IKZF1 A422V unknown
IKZF1 A441T unknown
IKZF1 A448R no effect - predicted
IKZF1 A79E unknown
IKZF1 A79V unknown
IKZF1 amp no effect
IKZF1 C150R loss of function
IKZF1 C203W unknown
IKZF1 D22N unknown
IKZF1 D28N unknown
IKZF1 D399G unknown
IKZF1 del loss of function
IKZF1 E300K unknown
IKZF1 E304K unknown
IKZF1 E401K unknown
IKZF1 E405K unknown
IKZF1 E465K unknown
IKZF1 E513K unknown
IKZF1 G106E unknown
IKZF1 G190S unknown
IKZF1 G337S no effect - predicted
IKZF1 G43E unknown
IKZF1 G485D unknown
IKZF1 G485V unknown
IKZF1 G496C unknown
IKZF1 G75V unknown
IKZF1 G94A unknown
IKZF1 H119R unknown
IKZF1 H176L unknown
IKZF1 H432R unknown
IKZF1 H508R unknown
IKZF1 inact mut loss of function
IKZF1 K116fs loss of function - predicted
IKZF1 K286* loss of function - predicted
IKZF1 L132F unknown
IKZF1 L283I unknown
IKZF1 M494fs unknown
IKZF1 M494V unknown
IKZF1 M92I unknown
IKZF1 mutant unknown
IKZF1 P19L unknown
IKZF1 P19T unknown
IKZF1 P233Q unknown
IKZF1 P34S unknown
IKZF1 R143Q unknown
IKZF1 R143W loss of function
IKZF1 R162Q loss of function
IKZF1 R213* loss of function - predicted
IKZF1 R222C unknown
IKZF1 R222L unknown
IKZF1 R260K unknown
IKZF1 R423H unknown
IKZF1 R433S unknown
IKZF1 R502W unknown
IKZF1 R511* unknown
IKZF1 R511P unknown
IKZF1 R51T unknown
IKZF1 R83* loss of function - predicted
IKZF1 R83Q unknown
IKZF1 R97M unknown
IKZF1 S384fs unknown
IKZF1 S393R unknown
IKZF1 S427L unknown
IKZF1 S88L unknown
IKZF1 T333M unknown
IKZF1 V139A unknown
IKZF1 V53M unknown
IKZF1 wild-type no effect