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Gene Symbol POLD3
Synonyms IMD122 | P66 | P68 | PPP1R128
Gene Description POLD3, DNA polymerase delta 3, accessory subunit, is one of four subunits that form the DNA polymerase delta holoenzyme, which mediates DNA replication (PMID: 27320729, PMID: 29447390) and repair (PMID: 31954770), and is required for genome stability (PMID: 27974823). POLD3 amplification and mutations have been identified in colorectal cancer (PMID: 17384679) and breast cancer (PMID: 19706770).
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