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Gene Symbol STAG2
Synonyms bA517O1.1 | HPE13 | MKMS | NEDXCF | SA-2 | SA2 | SCC3B
Gene Description STAG2, cohesin subunit SA-2, functions as part of the cohesin complex to regulate spindle formation and sister chromatid association in mitosis (PMID: 12034751, PMID: 24854081, PMID: 29175904). Somatic STAG2 mutations have been reported in glioblastoma, Ewing's sarcoma, bladder cancer, and melanoma, and loss of Stag2 expression has been demonstrated in a variety of other tumor types, including bladder cancer (PMID: 22668012, PMID: 28627627, PMID: 27207471, PMID: 29954776).

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Molecular Profile Protein Effect Treatment Approaches
STAG2 A300V unknown
STAG2 A532V unknown
STAG2 A998T unknown
STAG2 A998V unknown
STAG2 amp no effect
STAG2 C308R unknown
STAG2 C527F unknown
STAG2 C869R unknown
STAG2 D1055N unknown
STAG2 D1197N unknown
STAG2 D153N unknown
STAG2 D193N loss of function
BRAF V600E STAG2 D193N
STAG2 D385Y unknown
STAG2 D486N unknown
STAG2 D610G unknown
STAG2 D793K loss of function
STAG2 dec exp no effect
BRAF mut STAG2 dec exp
NRAS mut STAG2 dec exp
STAG2 E1005D unknown
STAG2 E1005K no effect - predicted
STAG2 E1107* unknown
STAG2 E134D unknown
STAG2 E251A unknown
STAG2 E276D unknown
STAG2 E276K no effect - predicted
STAG2 E342K no effect - predicted
STAG2 E523* loss of function - predicted
STAG2 E523K no effect - predicted
STAG2 E606A unknown
STAG2 E675D unknown
STAG2 E721V unknown
STAG2 E727D unknown
STAG2 E950* unknown
STAG2 H217R unknown
STAG2 H698R unknown
STAG2 H73Y unknown
STAG2 H832R unknown
STAG2 I201M unknown
STAG2 I522F unknown
STAG2 I829N unknown
STAG2 I855T unknown
STAG2 I910R unknown
STAG2 inact mut loss of function
STAG2 K1083* loss of function
BRAF V600E STAG2 K1083*
STAG2 K290E no effect - predicted
STAG2 K330E loss of function - predicted
STAG2 K346E no effect - predicted
STAG2 K363E no effect - predicted
STAG2 K870E loss of function - predicted
STAG2 K887E unknown
STAG2 K901E no effect - predicted
STAG2 K92N unknown
STAG2 K949N unknown
STAG2 L221M unknown
STAG2 L235Q unknown
STAG2 L237I unknown
STAG2 L366A no effect - predicted
STAG2 L405I unknown
STAG2 L526F unknown
STAG2 L571P unknown
STAG2 L858P unknown
STAG2 L961R unknown
STAG2 L997F unknown
STAG2 M224I unknown
STAG2 M796A no effect - predicted
STAG2 mutant unknown
STAG2 N357fs loss of function
STAG2 N412H unknown
STAG2 negative loss of function
STAG2 P160L unknown
STAG2 P572S unknown
STAG2 P987Q unknown
STAG2 P987T unknown
STAG2 Q1029* unknown
STAG2 Q185* loss of function - predicted
STAG2 Q185H unknown
STAG2 Q278E unknown
STAG2 Q593* loss of function - predicted
STAG2 R1012* unknown
STAG2 R1033* unknown
STAG2 R1045* unknown
STAG2 R1045Q unknown
STAG2 R110* loss of function - predicted
STAG2 R137I unknown
STAG2 R184W unknown
STAG2 R213E no effect - predicted
STAG2 R213T unknown
STAG2 R216* loss of function - predicted
STAG2 R216Q unknown
STAG2 R252Q unknown
STAG2 R259* loss of function - predicted
STAG2 R298C unknown
STAG2 R298E loss of function
STAG2 R305L unknown
STAG2 R370E no effect - predicted
STAG2 R370G unknown
STAG2 R370Q unknown
STAG2 R370W unknown
STAG2 R439H unknown
STAG2 R541K unknown
STAG2 R560E no effect - predicted
STAG2 R560W unknown
STAG2 R604* loss of function - predicted
STAG2 R614* loss of function - predicted
STAG2 R654I unknown
STAG2 R69Q unknown
STAG2 R861K unknown
STAG2 R862I unknown
STAG2 R908E no effect - predicted
STAG2 R953* unknown
STAG2 R954H unknown
STAG2 S1058* unknown
STAG2 S105L unknown
STAG2 S156G unknown
STAG2 S219G unknown
STAG2 S419* loss of function - predicted
STAG2 S653* loss of function
STAG2 S704L unknown
STAG2 T1027A unknown
STAG2 T626fs loss of function - predicted
STAG2 T966K unknown
STAG2 V181A unknown
STAG2 V181L unknown
STAG2 V465F unknown
STAG2 V620L unknown
STAG2 V783F unknown
STAG2 W102* loss of function - predicted
STAG2 W334A loss of function
STAG2 W706G unknown
STAG2 W706L unknown
STAG2 Y297A loss of function
STAG2 Y331A loss of function
STAG2 Y414F unknown
STAG2 Y479A no effect - predicted
STAG2 Y594* loss of function - predicted
STAG2 Y636* loss of function - predicted