Gene Detail


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Gene Symbol KDM5B
Synonyms CT31 | JARID1B | MRT65 | PLU-1 | PLU1 | PPP1R98 | PUT1 | RBBP2H1A | RBP2-H1
Gene Description KDM5B, lysine demethylase 5B, is a histone demethylase regulating gene transcription through H3K4 histone and chromatin modification to regulate cell growth and proliferation (PMID: 32155529, PMID: 30448242). Abnormal Kdm5b expression has been reported in multiple cancer types including breast, prostate, bladder, and lung (PMID: 24937458) and overexpression has been associated with poor prognosis in laryngeal squamous cell carcinoma (PMID: 31934196) and hepatocellular carcinoma (PMID: 30344945).
Additional content available in CKB BOOST