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Gene Symbol CHEK1
Synonyms CHK1
Gene Description CHEK1, checkpoint kinase 1, is a tumor suppressor (PMID: 30562755) and serine/threonine kinase activated in response to DNA damage that is responsible for mediating checkpoint signaling from ATM and ATR (PMID: 23613359, PMID: 12781359). Overexpression of Chek1 has been observed in several tumor types, including gastric cancer, small cell lung cancer, and T-cell leukemia (PMID: 25132270, PMID: 26867682, PMID: 28490518).


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