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Gene Symbol MAP4K1
Synonyms HPK1
Gene Description MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1, is a member of the MAPK4 family of serine/threonine kinases that plays a role in negative regulation of T-cell activation and proliferation, and regulates cell signaling pathways involved in cell growth, differentiation, and apoptosis (PMID: 31766293, PMID: 15770651). MAPK41 expression loss has been demonstrated in pancreatic ductal adenocarcinoma (PMID: 19141650).


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