Gene Detail

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Gene Symbol CHEK2
Synonyms CDS1 | CHK2 | hCds1 | HuCds1 | LFS2 | PP1425 | RAD53 | TPDS4
Gene Description CHEK2, checkpoint kinase 2, is a serine-threonine protein kinase and a putative tumor suppressor (PMID: 30562755) required for checkpoint-mediated cell cycle arrest and activation of DNA repair and apoptosis in response to DNA damage (PMID: 28553140). CHEK2 alterations are associated with predisposition to certain human cancers, including breast, prostate, kidney, and colon (PMID: 24880342; PMID: 24713400, PMID: 28553140).

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Molecular Profile Protein Effect Treatment Approaches
CHEK2 A17S no effect - predicted
CHEK2 A230P loss of function - predicted Olaparib
CHEK2 A237T loss of function - predicted Olaparib
CHEK2 A247D loss of function Olaparib
CHEK2 A247T unknown
CHEK2 A334T no effect - predicted
CHEK2 A392P loss of function - predicted Olaparib
CHEK2 A392S loss of function - predicted Olaparib
CHEK2 A392V loss of function Olaparib
CHEK2 A480T unknown
CHEK2 A541G unknown
CHEK2 amp no effect
CHEK2 C108R loss of function - predicted Olaparib
CHEK2 C243R no effect
CHEK2 C284Y loss of function Olaparib
CHEK2 C385R loss of function - predicted Olaparib
CHEK2 C420T loss of function - predicted Olaparib
CHEK2 D134H no effect - predicted
CHEK2 D134Y unknown
CHEK2 D162G loss of function - predicted Olaparib
CHEK2 D203G unknown
CHEK2 D207V no effect - predicted
CHEK2 D265_H282del loss of function Olaparib
CHEK2 D293fs loss of function - predicted Olaparib
CHEK2 D311N no effect - predicted
CHEK2 D347A loss of function Olaparib
CHEK2 D347N loss of function Olaparib
CHEK2 D409N loss of function Olaparib
CHEK2 D438G no effect - predicted
CHEK2 D438Y unknown Olaparib
CHEK2 D490E no effect - predicted
CHEK2 D497N no effect - predicted
CHEK2 D82_E86del loss of function - predicted Olaparib
CHEK2 dec exp no effect
BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos
CHEK2 del loss of function Olaparib
CHEK2 E107_K197del loss of function - predicted Olaparib
CHEK2 E122Dfs*8 loss of function - predicted Olaparib
CHEK2 E149Ifs*6 loss of function - predicted Olaparib
CHEK2 E161del loss of function Olaparib
CHEK2 E239K loss of function Olaparib
CHEK2 E239Q no effect - predicted
CHEK2 E263Q no effect - predicted
CHEK2 E273K loss of function - predicted Olaparib
CHEK2 E275* loss of function - predicted Olaparib
CHEK2 E275K unknown
CHEK2 E305G unknown
CHEK2 E321* loss of function - predicted Olaparib
CHEK2 E321K loss of function Olaparib
CHEK2 E351D unknown
CHEK2 E351K loss of function Olaparib
CHEK2 E377G no effect - predicted
CHEK2 E394K loss of function Olaparib
CHEK2 E454V unknown
CHEK2 E501K no effect - predicted
CHEK2 E504Q no effect - predicted
CHEK2 E528K no effect - predicted
CHEK2 E531Q no effect - predicted
CHEK2 E64K loss of function Olaparib
CHEK2 E87* loss of function - predicted Olaparib
CHEK2 F103L no effect - predicted
CHEK2 F125S loss of function - predicted Olaparib
CHEK2 F169L loss of function - predicted Olaparib
CHEK2 F169Lfs*2 loss of function - predicted Olaparib
CHEK2 F202fs loss of function - predicted Olaparib
CHEK2 F292fs loss of function - predicted Olaparib
CHEK2 F475I no effect - predicted
CHEK2 F475Lfs*7 loss of function - predicted Olaparib
CHEK2 G102V unknown
CHEK2 G116A unknown
CHEK2 G14Afs*47 loss of function - predicted Olaparib
CHEK2 G151C no effect - predicted
CHEK2 G167R loss of function Olaparib
CHEK2 G229D unknown
CHEK2 G229S loss of function - predicted Olaparib
CHEK2 G232R unknown
CHEK2 G306A loss of function Olaparib
CHEK2 G306E loss of function - predicted Olaparib
CHEK2 G306W unknown
CHEK2 G342S no effect - predicted
CHEK2 G370E loss of function - predicted Olaparib
CHEK2 G386R loss of function - predicted Olaparib
CHEK2 G414E loss of function - predicted Olaparib
CHEK2 H143R loss of function - predicted Olaparib
CHEK2 H143Y loss of function - predicted Olaparib
CHEK2 H282Y unknown
CHEK2 H339Y unknown
CHEK2 H371Y unknown Olaparib
CHEK2 H483R loss of function - predicted Olaparib
CHEK2 H54Pfs*6 loss of function - predicted Olaparib
CHEK2 I157S no effect - predicted
CHEK2 I157T loss of function - predicted Olaparib
CHEK2 I160M loss of function - predicted Olaparib
CHEK2 I160R loss of function - predicted Olaparib
CHEK2 I160T loss of function - predicted Olaparib
CHEK2 I189V loss of function - predicted Olaparib
CHEK2 I221M no effect - predicted
CHEK2 I221V no effect - predicted
CHEK2 I251F unknown
CHEK2 I251M unknown
CHEK2 I276S unknown
CHEK2 I364T unknown
CHEK2 I448S unknown
CHEK2 inact mut loss of function Olaparib
CHEK2 inact mut FANCA inact mut PTEN inact mut
CHEK2 K135Nfs*26 loss of function - predicted Olaparib
CHEK2 K135T unknown
CHEK2 K141T unknown
CHEK2 K224E loss of function - predicted Olaparib
CHEK2 K244R no effect - predicted Olaparib
CHEK2 K249N unknown
CHEK2 K249R loss of function - predicted Olaparib
CHEK2 K253* loss of function - predicted Olaparib
CHEK2 K279T unknown
CHEK2 K287fs loss of function - predicted Olaparib
CHEK2 K373E loss of function Olaparib
CHEK2 K373R no effect - predicted
CHEK2 K437E no effect
CHEK2 L174F no effect - predicted
CHEK2 L174V loss of function - predicted Olaparib
CHEK2 L183F loss of function - predicted Olaparib
CHEK2 L183S loss of function - predicted Olaparib
CHEK2 L216* loss of function - predicted Olaparib
CHEK2 L226F unknown
CHEK2 L236P loss of function - predicted Olaparib
CHEK2 L309P loss of function - predicted Olaparib
CHEK2 L326P loss of function - predicted Olaparib
CHEK2 L338F no effect - predicted
CHEK2 L338R unknown
CHEK2 L354V unknown
CHEK2 L355P unknown
CHEK2 L396V unknown
CHEK2 L512V no effect - predicted
CHEK2 L543S unknown
CHEK2 loss loss of function Olaparib
CHEK2 M222V no effect - predicted
CHEK2 M304T loss of function - predicted Olaparib
CHEK2 M381* loss of function - predicted Olaparib
CHEK2 M381V no effect - predicted
CHEK2 mutant unknown
ATM mut CHEK2 mut
CHEK2 N166S loss of function - predicted Olaparib
CHEK2 N185fs loss of function - predicted Olaparib
CHEK2 N185T unknown
CHEK2 N186H no effect
CHEK2 N281S no effect - predicted
CHEK2 N290Ifs*15 loss of function - predicted Olaparib
CHEK2 N352D loss of function - predicted Olaparib
CHEK2 N405K no effect - predicted
CHEK2 N446D no effect
CHEK2 over exp no effect
CHEK2 P182H unknown
CHEK2 P182L unknown
CHEK2 P182T no effect - predicted
CHEK2 P21T no effect - predicted
CHEK2 P425L unknown
CHEK2 P426H unknown
CHEK2 P426R loss of function - predicted Olaparib
CHEK2 P484L no effect - predicted
CHEK2 P484T no effect - predicted
CHEK2 P509S unknown
CHEK2 P536L unknown
CHEK2 P80H no effect - predicted
CHEK2 P85L unknown Olaparib
CHEK2 P85R loss of function - predicted Olaparib
CHEK2 P90S unknown
CHEK2 Q10fs loss of function - predicted Olaparib
CHEK2 Q209* loss of function Olaparib
CHEK2 Q27* loss of function - predicted Olaparib
CHEK2 Q34Vfs*42 loss of function - predicted Olaparib
CHEK2 Q487R unknown
CHEK2 R117A loss of function Olaparib
CHEK2 R117G loss of function Olaparib
CHEK2 R137Q no effect - predicted
CHEK2 R145Q no effect - predicted
CHEK2 R145W loss of function Olaparib
CHEK2 R148G loss of function - predicted Olaparib
CHEK2 R148T no effect - predicted
CHEK2 R180C unknown
CHEK2 R180H loss of function - predicted Olaparib
CHEK2 R181C unknown Olaparib
CHEK2 R181H no effect
CHEK2 R318C no effect - predicted
CHEK2 R318H loss of function - predicted Olaparib
CHEK2 R346C unknown
CHEK2 R346G unknown
CHEK2 R346H unknown
CHEK2 R346S unknown
CHEK2 R382* loss of function - predicted Olaparib
CHEK2 R3W unknown
CHEK2 R406C no effect - predicted
CHEK2 R406H unknown
CHEK2 R406Vfs*8 loss of function - predicted Olaparib
CHEK2 R474C loss of function Olaparib
CHEK2 R474H loss of function Olaparib
CHEK2 R474L loss of function - predicted Olaparib
CHEK2 R519* unknown
CHEK2 R519G unknown
CHEK2 R521Q unknown
CHEK2 R521W unknown
CHEK2 R523C no effect - predicted
CHEK2 R523fs unknown
CHEK2 R95* loss of function - predicted Olaparib
CHEK2 S140N loss of function - predicted Olaparib
CHEK2 S24C unknown
CHEK2 S357F loss of function - predicted Olaparib
CHEK2 S372F loss of function - predicted Olaparib
CHEK2 S372Y loss of function - predicted Olaparib
CHEK2 S39F no effect - predicted
CHEK2 S412R loss of function - predicted Olaparib
CHEK2 S422Vfs*15 loss of function - predicted Olaparib
CHEK2 S428F loss of function - predicted Olaparib
CHEK2 S49F unknown
CHEK2 S505T no effect - predicted
CHEK2 S57F no effect - predicted
CHEK2 S5L no effect - predicted
CHEK2 T168I unknown
CHEK2 T172A no effect - predicted
CHEK2 T205S no effect - predicted
CHEK2 T323P unknown Olaparib
CHEK2 T366fs loss of function - predicted Olaparib
CHEK2 T367fs loss of function Olaparib
CHEK2 T367Mfs*15 loss of function Olaparib
CHEK2 T378I no effect - predicted
CHEK2 T387S loss of function - predicted Olaparib
CHEK2 T410fs loss of function Olaparib
CHEK2 T476K loss of function - predicted Olaparib
CHEK2 T476M loss of function Olaparib
CHEK2 T532I unknown
CHEK2 T533A no effect - predicted
CHEK2 T59K loss of function - predicted Olaparib
CHEK2 V109A unknown
CHEK2 V175A no effect - predicted
CHEK2 V198Ffs*7 loss of function - predicted Olaparib
CHEK2 V198I unknown
CHEK2 V200A unknown
CHEK2 V25I unknown
CHEK2 V395L unknown
CHEK2 W485G loss of function - predicted Olaparib
CHEK2 W93Gfs*17 loss of function - predicted Olaparib
CHEK2 W93R loss of function - predicted Olaparib
CHEK2 wild-type no effect
CHEK2 Y123C no effect - predicted
CHEK2 Y139* loss of function - predicted Olaparib
CHEK2 Y159H no effect - predicted
CHEK2 Y327C unknown
CHEK2 Y390C loss of function Olaparib
CHEK2 Y390S loss of function Olaparib
CHEK2 Y404C unknown
CHEK2 Y424H loss of function - predicted Olaparib