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|Gene Description||U2AF2, U2 small nuclear RNA auxiliary factor 2, is the large subunit of the U2 auxiliary factor, which recognizes regulatory RNA sequence motifs at the 3' splice site region (PMID: 32303702) and initiates spliceosome assembly (PMID: 1824937, PMID: 27799531). U2AF2 mutations have been identified in a variety of hematologic and solid tumors (PMID: 28850223).|