Gene Detail


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Gene Symbol NLRP3
Synonyms AGTAVPRL | AII | AVP | C1orf7 | CIAS1 | CLR1.1 | DFNA34 | FCAS | FCAS1 | FCU | KEFH | MWS | NALP3 | PYPAF1
Gene Description NLRP3, NLR family pyrin domain containing 3, is a member of the NOD-like receptor family that functions as a sensor protein in the NLRP3 inflammasome, which plays a role in immune response (PMID: 23066025, PMID: 27551512, PMID: 36275641). Altered expression of NLRP3 has been identified in several tumor types (PMID: 35026655), including increased expression in head and neck squamous cell carcinoma (PMID: 28865486) and decreased expression in hepatocellular carcinoma (PMID: 24166187).
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