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Gene Symbol AGAP3
Synonyms AGAP-3 | CENTG3 | cnt-g3 | CRAG | MRIP-1
Gene Description AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, is a GTPase (PMID: 16461359) that regulates Ras/ERK and Arf6 signaling pathways and plays a role in synaptic plasticity (PMID: 23904596). An AGAP3-BRAF fusion has been identified in MSI-high colorectal cancer (PMID: 30279230) and melanoma (PMID: 28539463), and a HOXD11-AGAP3 fusion has been identified in a neuroblastic tumor (PMID: 31698611).
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