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Gene Symbol CREBBP
Synonyms CBP | KAT3A | MKHK1 | RSTS | RSTS1
Gene Description CREBBP, CREB-binding protein, is an acetyltransferase (PMID: 30181244) that plays a key role in transcription regulation for a number of different genes involved in a variety of cellular processes including proliferation, differentiation, apoptosis, and DNA repair (PMID: 27380996, PMID: 20435671). Expression, mutations and chromosomal translocations of CREBBP have been associated with various human cancers (PMID: 23839013; PMID: 21390130; PMID: 23022987; PMID: 9290955), including glioblastoma, leukemia (PMID: 21390130, PMID: 21390126, PMID: 25423036), and small cell lung cancer (PMID: 30181244).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
1387 16 16p13.3 NM_004380 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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