Gene Detail

Gene Symbol AMER1
Synonyms FAM123B | OSCS | WTX
Gene Description AMER1, APC membrane recruitment protein 1, is part of the beta-catenin complex and plays a role in Wnt signaling regulation, and also binds to Apc to regulate its distribution within the cell (PMID: 26071483, PMID: 17925383, PMID: 17510365). AMER1 is a putative tumor suppressor in pancreatic and colorectal adenocarcinomas (PMID: 29625053) and mutations in AMER1 are associated with Wilms tumor (PMID: 21498506).
Entrez Id 139285
Chromosome X
Map Location Xq11.2
Canonical Transcript NM_152424

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