Gene Detail
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| Gene Symbol | AMER1 | ||||||||||
| Synonyms | FAM123B | OSCS | WTX | ||||||||||
| Gene Description | AMER1, APC membrane recruitment protein 1, is a scaffold protein that promotes beta-catenin degradation through recruiting and stabilizing components of the beta-catenin degradation complex to the membrane, thus inhibits Wnt/beta-catenin signaling (PMID: 17925383, PMID: 17510365, PMID: 21498506). AMER1 is frequently mutated in colorectal cancer (PMID: 26071483) and Wilms tumor (PMID: 28825729, PMID: 28326956). | ||||||||||
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