Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | SIRPA | ||||||||||
| Synonyms | BIT | CD172A | MFR | MYD-1 | P84 | PTPNS1 | SHPS1 | SIRP | ||||||||||
| Gene Description | SIRPA, signal regulatory protein alpha, is a tyrosine-protein phosphatase non-receptor that is predominately expressed on the cell surface of macrophages and is a receptor for CD47, which upon binding inhibits phagocytosis (PMID: 29930800). Sirpa altered expression has been reported in a variety of tumor types and therapeutic disruption of binding of CD47 to the Sirpa receptor on macrophages may stimulate phagocytosis of tumor cells (PMID: 28286286, PMID: 28258703). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
