Gene Detail


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Gene Symbol PARP1
Synonyms ADPRT | ADPRT 1 | ADPRT1 | ARTD1 | pADPRT-1 | PARP | PARP-1 | PARS | Poly-PARP | PPOL
Gene Description PARP1, poly (ADP-ribose) polymerase 1, is an enzyme that catalyzes poly (ADP-ribosyl)ation of proteins, which initiates cellular response to DNA damage (PMID: 15743666) to repair single strand breaks through base excision repair and nucleotide excision repair (PMID: 32722408). PARP1 dysregulation has been identified in acute myeloid leukemia, breast and colorectal cancers (PMID: 25483710, PMID: 25528020, PMID: 16809031), and mutations may confer resistance to PARP inhibitors (PMID: 32722408).
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