Gene Detail


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Gene Symbol DAXX
Synonyms BING2 | DAP6 | EAP1 | SMIM40
Gene Description DAXX, death-domain associated protein 6, is a transcriptional co-regulator that represses activity of transcriptional factors including C/EBPB, c-Met, Pax3, Ets1, p53, AR, and SMAD4 (PMID: 23539629). Loss of Daxx expression has been linked to ovarian cancer and pancreatic neuroendocrine tumors, while overexpression has been observed in oral squamous cell carcinoma and prostate cancer (PMID: 26205068, PMID: 27162024, PMID: 23954140, PMID: 23642739).

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