Gene Detail

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Gene Symbol

DAXX

Synonyms

BING2 | DAP6 | EAP1 | SMIM40

Gene Description

DAXX, death domain associated protein, is a transcriptional co-regulator that represses activity of transcriptional factors including C/EBPB, c-Met, Pax3, Ets1, p53, AR, and SMAD4 (PMID: 23539629, PMID: 31350900). Loss of Daxx expression has been linked to ovarian cancer and pancreatic neuroendocrine tumors, while overexpression has been observed in oral squamous cell carcinoma and prostate cancer (PMID: 26205068, PMID: 27162024, PMID: 23954140, PMID: 23642739), and DAXX mutations have been observed in pancreatic neuroendocrine tumors (PMID: 31819132).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
1616	6	6p21.32	NM_001350	Both: Oncogene and Tumor suppressor (PMID: 30606230)