Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol DAXX
Synonyms BING2 | DAP6 | EAP1 | SMIM40
Gene Description DAXX, death domain associated protein, is a transcriptional co-regulator that represses activity of transcriptional factors including C/EBPB, c-Met, Pax3, Ets1, p53, AR, and SMAD4 (PMID: 23539629, PMID: 31350900). Loss of Daxx expression has been linked to ovarian cancer and pancreatic neuroendocrine tumors, while overexpression has been observed in oral squamous cell carcinoma and prostate cancer (PMID: 26205068, PMID: 27162024, PMID: 23954140, PMID: 23642739), and DAXX mutations have been observed in pancreatic neuroendocrine tumors (PMID: 31819132).
Additional content available in CKB BOOST