Gene Detail

Gene Symbol ASXL1
Synonyms BOPS | MDS
Gene Description ASXL1, additional sex combs like 1, transcriptional regulator, is involved in epigenetic regulation of gene expression and forms complexes with several proteins to regulate transcription (PMID: 23736028). Mutations in ASXL1 are frequent in chronic myelomonocytic leukemia (PMID: 26771811, PMID: 23736028), and have been identified in a number of different tumor types including acute myeloid leukemia and liver cancer (PMID: 23736028).
Entrez Id 171023
Chromosome 20
Map Location 20q11.21
Canonical Transcript NM_015338

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Variant Impact Protein Effect Variant Description Associated with drug Resistance
A1312V missense unknown ASXL1 A1312V does not lie within any known functional domains of the Asxl1 protein (UniProt.org). A1312V has been identified in sequencing studies (PMID: 21712540), but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R545H missense unknown ASXL1 R545H lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). R545H has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G660D missense unknown ASXL1 G660D does not lie within any known functional domains of the Asxl1 protein (UniProt.org). G660D has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
E727K missense unknown ASXL1 E727K does not lie within any known functional domains of the Asxl1 protein (UniProt.org). E727K has been identified in sequencing studies (PMID: 27127140), but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
L1325F missense unknown ASXL1 L1325F does not lie within any known functional domains of the Asxl1 protein (UniProt.org). L1325F has been identified in sequencing studies (PMID: 21712540), but not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S441F missense unknown ASXL1 S441F lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). S441F has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G812C missense unknown ASXL1 G812C does not lie within any known functional domains of the Asxl1 protein (UniProt.org). G812C has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
amp none no effect ASXL1 amplification indicates an increased number of copies of the ASXL1 gene. However, the mechanism causing the increase is unspecified.
D544N missense unknown ASXL1 D544N lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). D544N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
E997* nonsense unknown ASXL1 E997* results in a premature truncation of the Asxl1 protein at amino acid 997 of 1541 (UniProt.org). E997* has not been characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R1273H missense unknown ASXL1 R1273H does not lie within any known functional domains of the Asxl1 protein (UniProt.org). R1273H has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R545P missense unknown ASXL1 R545P lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). R545P has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
P1360S missense unknown ASXL1 P1360S does not lie within any known functional domains of the Asxl1 protein (UniProt.org). P1360S has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Y591* nonsense unknown ASXL1 Y591* results in a premature truncation of the Asxl1 protein at amino acid 591 of 1541 (UniProt.org). Y591* has been identified in sequencing studies (PMID: 28076841) but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Q588R missense unknown ASXL1 Q588R lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). Q588R has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R549H missense unknown ASXL1 R549H lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). R549H has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
A158V missense unknown ASXL1 A158V does not lie within any known functional domains of the Asxl1 protein (UniProt.org). A158V has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
inact mut unknown loss of function ASXL1 inact mut indicates that this variant results in a loss of function of the Asxl1 protein. However, the specific amino acid change has not been identified.
R693* nonsense loss of function - predicted ASXL1 R693* results in a premature truncation of the Asxl1 protein at amino acid 693 of 1541 (UniProt.org). ASXL1 R693* has not been biochemically characterized, however, due to the effects of other ASXL1 truncation mutations that result in the loss of the PHD domain (PMID: 24216483, PMID: 22897849), R693* is predicted to result in a loss of Asxl1 function.
S791F missense unknown ASXL1 S791F does not lie within any known functional domains of the Asxl1 protein (UniProt.org). S791F has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
D1004N missense unknown ASXL1 D1004N does not lie within any known functional domains of the Asxl1 protein (UniProt.org). D1004N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
E537D missense unknown ASXL1 E537D lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). E537D has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
P1117L missense unknown ASXL1 P1117L does not lie within any known functional domains of the Asxl1 protein (UniProt.org). P1117L has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G1299D missense unknown ASXL1 G1299D does not lie within any known functional domains of the Asxl1 protein (UniProt.org). G1299D has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R1247C missense unknown ASXL1 R1247C does not lie within any known functional domains of the Asxl1 protein (UniProt.org). R1247C has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S120N missense unknown ASXL1 S120N does not lie within any known functional domains of the Asxl1 protein (UniProt.org). S120N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R419K missense unknown ASXL1 R419K lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). R419K has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
E1102D missense unknown ASXL1 E1102D does not lie within any known functional domains of the Asxl1 protein (UniProt.org). E1102D has been identified in sequencing studies (PMID: 29089644), but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
M1161I missense unknown ASXL1 M1161I does not lie within any known functional domains of the Asxl1 protein (UniProt.org). M1161I has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R1090T missense unknown ASXL1 R1090T does not lie within any known functional domains of the Asxl1 protein (UniProt.org). R1090T has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
V1246D missense unknown ASXL1 V1246D does not lie within any known functional domains of the Asxl1 protein (UniProt.org). V1246D has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Q1491* nonsense unknown ASXL1 Q1491* results in a premature truncation of the Asxl1 protein at amino acid 1491 of 1541 (UniProt.org). Q1491* has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
A498S missense unknown ASXL1 A498S lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). A498S has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G643fs frameshift loss of function - predicted ASXL1 G643fs results in a change in the amino acid sequence of the Asxl1 protein beginning at aa 643 of 1541, likely resulting in premature truncation of the functional protein (UniProt.org). G643fs has not been characterized, however, due to the effects of other ASXL1 truncation mutations, G643fs is predicted to result in a loss of Asxl1 function (PMID: 24216483, PMID: 22897849).
W796C missense unknown ASXL1 W796C does not lie within any known functional domains of the Asxl1 protein (UniProt.org). W796C has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G967del missense unknown ASXL1 G967del results in the deletion of one amino acid in the Asxl1 protein at amino acid 967 (UniProt.org). G967del has been identified in sequencing studies (PMID: 21712540), but not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S723F missense unknown ASXL1 S723F does not lie within any known functional domains of the Asxl1 protein (UniProt.org). S723F has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G685R missense unknown ASXL1 G685R does not lie within any known functional domains of the Asxl1 protein (UniProt.org). G685R has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
L56I missense unknown ASXL1 L56I lies within the ASXN domain of the Asxl1 protein (PMID: 19609284). L56I has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R302C missense unknown ASXL1 R302C lies within the ASXM domain of the Asxl1 protein (PMID: 19609284). R302C has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S577* nonsense unknown ASXL1 S577* results in a premature truncation of the Asxl1 protein at amino acid 577 of 1541 (UniProt.org). S577* has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
M29V missense unknown ASXL1 M29V does not lie within any known functional domains of the Asxl1 protein (UniProt.org). M29V has been identified in sequencing studies (PMID: 21455215), but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
wild-type none no effect Wild-type ASXL1 indicates that no mutation has been detected within the ASXL1 gene.
R244H missense unknown ASXL1 R244H lies within the ASXM domain of the Asxl1 protein (PMID: 19609284). R244H has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
D756N missense unknown ASXL1 D756N does not lie within any known functional domains of the Asxl1 protein (UniProt.org). D756N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R143* nonsense loss of function - predicted ASXL1 R143* results in a premature truncation of the Asxl1 protein at amino acid 143 of 1541 (UniProt.org). Due to the loss of most known functional domains (UniProt.org), R143* is predicted to lead to a loss of Asxl1 protein function.
P1392L missense unknown ASXL1 P1392L does not lie within any known functional domains of the Asxl1 protein (UniProt.org). P1392L has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R1415* nonsense unknown ASXL1 R1415* results in a premature truncation of the Asxl1 protein at amino acid 1415 of 1541 (UniProt.org). R1415* has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S1209N missense unknown ASXL1 S1209N does not lie within any known functional domains of the Asxl1 protein (UniProt.org). S1209N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R1090K missense unknown ASXL1 R1090K does not lie within any known functional domains of the Asxl1 protein (UniProt.org). R1090K has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
L1467I missense unknown ASXL1 L1467I does not lie within any known functional domains of the Asxl1 protein (UniProt.org). L1467I has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
A54S missense unknown ASXL1 A54S lies within the ASXN domain of the Asxl1 protein (PMID: 19609284). A54S has not been characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
I579S missense unknown ASXL1 I579S lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). I579S has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
S203F missense unknown ASXL1 S203F does not lie within any known functional domains of the Asxl1 protein (UniProt.org). S203F has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G645Vfs*58 frameshift loss of function - predicted ASXL1 G645Vfs*58 indicates a shift in the reading frame starting at amino acid 645 and terminating 58 residues downstream causing a premature truncation of the 1541 amino acid Asxl1 protein (UniProt.org). G645Vfs*58 has not been characterized, however, due to the effects of other ASXL1 truncation mutations (PMID: 24216483, PMID: 22897849), G645Vfs*58 is predicted to result in a loss of Asxl1 function.
E865K missense unknown ASXL1 E865K does not lie within any known functional domains of the Asxl1 protein (UniProt.org). E865K has not been characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Q512* nonsense unknown ASXL1 Q512* results in a premature truncation of the Asxl1 protein at amino acid 512 of 1541 (UniProt.org). Q512* has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
mutant none unknown ASXL1 mutant indicates an unspecified mutation in the ASXL1 gene.
R965* nonsense unknown ASXL1 R965* results in a premature truncation of the Asxl1 protein at amino acid 965 of 1541 (UniProt.org). R965* has not been characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
K162E missense unknown ASXL1 K162E does not lie within any known functional domains of the Asxl1 protein (UniProt.org). K162E has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
P494S missense unknown ASXL1 P494S lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). P494S has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Q733* nonsense unknown ASXL1 Q733* results in a premature truncation of the Asxl1 protein at amino acid 733 of 1541 (UniProt.org). Q733* has not been characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G42* nonsense loss of function - predicted ASXL1 G42* results in a premature truncation of the Asxl1 protein at amino acid 42 of 1541 (UniProt.org). Due to the loss of most known functional domains (UniProt.org), G42* is predicted to lead to a loss of Asxl1 protein function.
E1228* nonsense unknown ASXL1 E1228* results in a premature truncation of the Asxl1 protein at amino acid 1228 of 1541 (UniProt.org). E1228* has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
K383* nonsense loss of function - predicted ASXL1 K383* results in a premature truncation of the Asxl1 protein at amino acid 383 of 1541 (UniProt.org). K383* has not been characterized, however, due to the effects of other ASXL1 truncation mutations (PMID: 24216483, PMID: 22897849), K383* is predicted to result in a loss of Asxl1 protein function.
A627V missense unknown ASXL1 A627V lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). A627V has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
D475N missense unknown ASXL1 D475N lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). D475N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
P567L missense unknown ASXL1 P567L lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). P567L has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
R265H missense unknown ASXL1 R265H lies within the ASXM domain of the Asxl1 protein (PMID: 19609284). R265H has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
G679* nonsense unknown ASXL1 G679* results in a premature truncation of the Asxl1 protein at amino acid 679 of 1541 (UniProt.org). G679* has been identified in sequencing studies (PMID: 24212482), but has not been biochemically characterized and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
L145F missense unknown ASXL1 L145F does not lie within any known functional domains of the Asxl1 protein (UniProt.org). L145F has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
K163T missense unknown ASXL1 K163T does not lie within any known functional domains of the Asxl1 protein (UniProt.org). K163T has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
A158T missense unknown ASXL1 A158T does not lie within any known functional domains of the Asxl1 protein (UniProt.org). A158T has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
A1312S missense unknown ASXL1 A1312S does not lie within any known functional domains of the Asxl1 protein (UniProt.org). A1312S has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
D521N missense unknown ASXL1 D521N lies within the NCOA1-interacting region of the Asxl1 protein (UniProt.org). D521N has not been characterized in the scientific literature and therefore, its effect on Asxl1 protein function is unknown (PubMed, Feb 2018).
Molecular Profile Protein Effect Treatment Approaches
ASXL1 A1312V unknown
ASXL1 R545H unknown
ASXL1 G660D unknown
ASXL1 E727K unknown
ASXL1 L1325F unknown
ASXL1 S441F unknown
ASXL1 G812C unknown
ASXL1 amp no effect
ASXL1 D544N unknown
ASXL1 E997* unknown
ASXL1 R1273H unknown
ASXL1 R545P unknown
ASXL1 P1360S unknown
ASXL1 Y591* unknown
ASXL1 Q588R unknown
ASXL1 R549H unknown
ASXL1 A158V unknown
ASXL1 inact mut loss of function
ASXL1 R693* loss of function - predicted
ASXL1 S791F unknown
ASXL1 D1004N unknown
ASXL1 E537D unknown
ASXL1 P1117L unknown
ASXL1 G1299D unknown
ASXL1 R1247C unknown
ASXL1 S120N unknown
ASXL1 R419K unknown
ASXL1 E1102D unknown
ASXL1 M1161I unknown
ASXL1 R1090T unknown
ASXL1 V1246D unknown
ASXL1 Q1491* unknown
ASXL1 A498S unknown
ASXL1 G643fs loss of function - predicted
ASXL1 W796C unknown
ASXL1 G967del unknown
ASXL1 S723F unknown
ASXL1 G685R unknown
ASXL1 L56I unknown
ASXL1 R302C unknown
ASXL1 S577* unknown
ASXL1 M29V unknown
ASXL1 wild-type no effect
ASXL1 wild-type CALR mut
ASXL1 wild-type TET2 mutant
ASXL1 wild-type CALR wild-type
ASXL1 R244H unknown
ASXL1 D756N unknown
ASXL1 R143* loss of function - predicted
ASXL1 P1392L unknown
ASXL1 R1415* unknown
ASXL1 S1209N unknown
ASXL1 R1090K unknown
ASXL1 L1467I unknown
ASXL1 A54S unknown
ASXL1 I579S unknown
ASXL1 S203F unknown
ASXL1 G645Vfs*58 loss of function - predicted
ASXL1 E865K unknown
ASXL1 Q512* unknown
ASXL1 mut TET2 mut
ASXL1 mut CALR mut
ASXL1 mut CALR wild-type
ASXL1 mutant unknown
ASXL1 R965* unknown
ASXL1 K162E unknown
ASXL1 P494S unknown
ASXL1 Q733* unknown
ASXL1 G42* loss of function - predicted
ASXL1 E1228* unknown
ASXL1 K383* loss of function - predicted
ASXL1 A627V unknown
ASXL1 D475N unknown
ASXL1 P567L unknown
ASXL1 R265H unknown
ASXL1 G679* unknown
ASXL1 L145F unknown
ASXL1 K163T unknown
ASXL1 A158T unknown
ASXL1 A1312S unknown
ASXL1 D521N unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ASXL1 inact mut myelodysplastic/myeloproliferative neoplasm not applicable N/A Clinical Study Prognostic In multiple clinical studies, nonsense and frameshift mutations in ASXL1 were associated with decreased overall survival in patients with chronic myelomonocytic leukemia (PMID: 26849014, PMID: 23690417, PMID: 20880116). 20880116 26849014 23690417
ASXL1 wild-type CALR mut myelofibrosis not applicable N/A Guideline Prognostic The presence of a CALR mutation combined with wild-type ASXL1 is associated with longer survival in patients with myelofibrosis (NCCN.org). detail...
ASXL1 wild-type TET2 mutant myelodysplastic/myeloproliferative neoplasm sensitive Azacitidine Clinical Study Actionable In a clinical study, myelodysplastic syndrome patients carrying TET2 mutations and wild-type ASXL1 demonstrated an increased response to treatment with the DNA hypomethylating agents Dacogen (decitabine) or Vidaza (azacitidine) compared to patients with other mutational profiles (65% vs. 44%; OR 2.37, P=0.49) (PMID: 25224413). 25224413
ASXL1 wild-type TET2 mutant myelodysplastic/myeloproliferative neoplasm sensitive Decitabine Clinical Study Actionable In a clinical study, myelodysplastic syndrome patients carrying TET2 mutations and wild-type ASXL1 demonstrated an increased response to treatment with the DNA hypomethylating agents Dacogen (decitabine) or Vidaza (azacitidine) compared to patients with other mutational profiles (65% vs. 44%; OR 2.37, P=0.49) (PMID: 25224413). 25224413
ASXL1 mut CALR mut myelofibrosis not applicable N/A Guideline Prognostic The presence of a CALR mutation combined with an ASXL1 mutation is associated with intermediate survival in patients with myelofibrosis (NCCN.org). detail...
ASXL1 mut CALR wild-type myelofibrosis not applicable N/A Guideline Prognostic The presence of an ASXL1 mutation combined with wild-type CALR is associated with shorter survival in patients with myelofibrosis (NCCN.org). detail...
ASXL1 mutant chronic myelomonocytic leukemia not applicable N/A Guideline Prognostic ASXL1 mutations are associated with a poor prognosis in patients with chronic myelomonocytic leukemia (NCCN.org). detail...
ASXL1 mutant myelofibrosis not applicable N/A Guideline Prognostic ASXL1 mutations are associated with inferior overall survival and leukemia-free survival in patients with myelofibrosis (NCCN.org). detail...
ASXL1 mutant myelodysplastic syndrome not applicable N/A Guideline Prognostic ASXL1 mutations are associated with a poor prognosis in patients with myelodysplastic syndrome (NCCN.org). detail...
ASXL1 mutant myelodysplastic syndrome not applicable N/A Clinical Study Prognostic In clinical analyses, mutations in ASXL1 were associated with poor prognosis in patients with myelodysplastic syndrome (PMID: 24220272, PMID: 21714648). 24220272 21714648