Gene Detail

Gene Symbol DPYD
Synonyms DHP | DHPDHASE | DPD
Gene Description DPYD, dihydropyrimidine dehydrogenase, is a rate-limiting enzyme involved in catabolism of pyrimidines, including uracil (PMID: 9830621, PMID: 26804652, PMID: 24648345). DPYD (DPD) deficiency, including via DPYD inactivating mutation, has been associated with increased risk of toxicity with fluoropyrimidine chemotherapy treatment, such as 5-fluorouracil (PMID: 9830621, PMID: 28481884, PMID: 24648345, PMID: 26804652, PMID: 14635116).
Entrez Id 1806
Chromosome 1
Map Location 1p21.3
Canonical Transcript NM_000110


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