Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol DPYD
Synonyms DHP | DHPDHASE | DPD | DYPD
Gene Description DPYD, dihydropyrimidine dehydrogenase, is a rate-limiting enzyme involved in catabolism of pyrimidines, including uracil (PMID: 9830621, PMID: 26804652, PMID: 24648345). DPYD deficiency, including inactivating mutations, has been associated with increased risk of toxicity with fluoropyrimidine chemotherapy treatments, such as 5-fluorouracil (PMID: 9830621, PMID: 28481884, PMID: 24648345, PMID: 26804652, PMID: 14635116).
Additional content available in CKB BOOST