Gene Detail

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Gene Symbol ERBB2
Synonyms CD340 | HER-2 | HER-2/neu | HER2 | MLN 19 | NEU | NGL | TKR1
Gene Description ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification and/or overexpression, and activation has been implicated in several tumor types (PMID: 17471238, PMID: 31019892), and is commonly observed in breast cancer (PMID: 31650186, PMID: 32161378), while some ERBB2 mutations have been implicated in resistance to select tyrosine kinase inhibitors (PMID: 32327210).

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Molecular Profile Protein Effect Treatment Approaches
ERBB2 A1216D no effect - predicted
ERBB2 A293T no effect - predicted
ERBB2 A386D unknown
ERBB2 A440T unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 A466V gain of function - predicted
ERBB2 A751T unknown
ERBB2 A771_Y772insAYVM gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 A775_G776insIRDG no effect - predicted
ERBB2 A775_G776insSVMA gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 A775_G776insYVMA gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 A775_G776insYVMA PIK3CA R425L
ERBB2 A890V unknown
ERBB2 act mut gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 act mut PIK3CA act mut
ERBB2 act mut STK11 loss
ERBB2 amp no effect HER inhibitor (Pan) HER2 (ERBB2) Antibody HER2 (ERBB2) Immune Cell Therapy HER2 (ERBB2) Vaccine HER2 Inhibitor
ERBB2 amp FGFR2 wild-type
ERBB2 amp PIK3CA C420R
ERBB2 amp PIK3CA N345K
ERBB2 amp PIK3CA H1047R
ERBB2 amp PIK3CA K111N
ERBB2 amp PIK3CA E545K
ERBB2 amp PIK3CA E545K PIK3CA K567R
ERBB2 amp PIK3CA mut
ERBB2 T798M ERBB2 amp
ERBB2 L866M ERBB2 amp
ERBB2 amp ERBB2 over exp
ERBB2 amp PIK3CA wild-type
ARID1A loss ERBB2 amp
ERBB2 amp FGFR2 amp
ERBB2 L755S ERBB2 amp
ERBB2 amp SRC E527K
ROS1 fusion ERBB2 amp NOTCH1 amp SRC amp STK11 amp
ROS1 fusion ERBB2 amp FGFR3 amp RET amp
ERBB2 S310F ERBB2 amp
ERBB2 Y772_A775dup ERBB2 amp
ERBB2 D769Y ERBB2 amp
ERBB2 V777L ERBB2 amp
ERBB2 L313I ERBB2 amp
ERBB2 R456C ERBB2 amp
ERBB2 amp NRAS wild-type
ERBB2 amp PIK3CA act mut
ERBB2 amp PIK3CA E542X
ERBB2 amp PIK3CA H1047X
ERBB2 amp PIK3CA E545X
BRAF wild-type ERBB2 amp NRAS wild-type
ERBB2 amp ERBB2 over exp ERBB2 rearrange
ERBB2 G778_P780dup ERBB2 amp
ERBB2 C311R gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 C334S gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 C515R gain of function - predicted
ERBB2 C544F unknown
ERBB2 C630Y unknown
ERBB2 C805S unknown
ERBB2 Y772_A775dup ERBB2 C805S
ERBB2 M774delinsWLV ERBB2 C805S
ERBB2 G776delinsVC ERBB2 C805S
ERBB2 D1058A no effect - predicted
ERBB2 D1144Y no effect - predicted
ERBB2 D251N unknown
ERBB2 D277G unknown
ERBB2 D277G ERBB2 S310F
ERBB2 D277H unknown
ERBB2 D277H ERBB2 S310F
ERBB2 D277Y no effect - predicted
ERBB2 D326G no effect
ERBB2 D417Y unknown
ERBB2 D582N no effect - predicted
ERBB2 D742H no effect - predicted
ERBB2 D742N unknown
ERBB2 D769A loss of function - predicted
ERBB2 D769H unknown
ERBB2 D769N unknown
ERBB2 D769Y gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 D821N gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 D845A loss of function
ERBB2 D880N no effect - predicted
ERBB2 dec exp no effect
ERBB2 E1021Q no effect - predicted
ERBB2 E1064Q no effect - predicted
ERBB2 E1195G unknown
ERBB2 E1229* unknown
ERBB2 E1244D no effect - predicted
ERBB2 E1244Q no effect - predicted
ERBB2 E139D no effect - predicted
ERBB2 E139G no effect - predicted
ERBB2 E265K unknown
ERBB2 E280K no effect - predicted
ERBB2 E321G gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 E693K gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 E717D gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 E717K unknown
ERBB2 E719G unknown
ERBB2 E719K unknown
ERBB2 E757A unknown
ERBB2 E812K unknown
ERBB2 E930D no effect - predicted
ERBB2 E930K no effect - predicted
ERBB2 E971G unknown
ERBB2 - TMEM98 unknown
ERBB2 exon 20 ins unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 exon20 unknown
ERBB2 F1030C no effect - predicted
ERBB2 F616L unknown
ERBB2 fusion unknown
ERBB2 G1015E unknown
ERBB2 G1015W no effect - predicted
ERBB2 G1041fs unknown
ERBB2 G222C unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G292R gain of function - predicted
ERBB2 G309A unknown
ERBB2 G309E unknown
ERBB2 G383E no effect - predicted
ERBB2 G660D gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S310F ERBB2 G660D
ERBB2 G660R gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776C unknown
ERBB2 G776delinsIC gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776delinsLC gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776delinsVC gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776delinsVV gain of function
ERBB2 G776R gain of function - predicted
ERBB2 G776S gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776V gain of function
ERBB2 G776V PIK3CA H1047R
ERBB2 G776_V777insVC gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776_V777insVC ERBB2 over exp
ERBB2 G776_V777insVGC gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G776_V777insYVMA gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G778A unknown
ERBB2 G778_P780dup gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G778_P780dup PIK3CA H1047R
ERBB2 G778_S779insCPG gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G778_S779insG gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G778_S779insLPS gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 G804D unknown
ERBB2 G804S unknown
ERBB2 G919W unknown
ERBB2 H473N no effect - predicted
ERBB2 H878Y gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 I101S no effect - predicted
ERBB2 I654V unknown
ERBB2 I655V no effect - predicted
ERBB2 I767M unknown
ERBB2 K228N no effect - predicted
ERBB2 K676R no effect
ERBB2 K681N unknown
ERBB2 K716E unknown
ERBB2 K716Q unknown
ERBB2 K753A loss of function - predicted
ERBB2 K753E unknown Neratinib
ERBB2 K753M loss of function - predicted
ERBB2 K831N unknown
ERBB2 K937R unknown
ERBB2 L1157R gain of function
ERBB2 L12R no effect - predicted
ERBB2 L145F no effect - predicted
ERBB2 L313I unknown
ERBB2 L313V unknown
ERBB2 L49H no effect
ERBB2 L663P unknown
ERBB2 L720V unknown
ERBB2 L726F gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L726I unknown
ERBB2 L755A unknown
ERBB2 L755M no effect - predicted
ERBB2 L755P gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L755S gain of function HER inhibitor (Pan) HER2 Inhibitor
APC Q1429fs BRAF N581S ERBB2 L755S
ERBB2 L755S ERBB2 V777L ERBB2 R1153*
ERBB2 L755S PIK3CA H1047R
ERBB2 L755W unknown
ERBB2 L755X unknown
ERBB2 L755_E757del unknown
ERBB2 L755_E757delinsS unknown
ERBB2 L755_T759del gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L768S gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L785F unknown
ERBB2 L786V gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L841V gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L866M gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 L869Q unknown
CDH1 R63* ERBB2 L869Q
ERBB2 L869R gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 T798I ERBB2 L869R
ERBB2 L915M unknown
ERBB2 M774delinsWLV gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 M774_A775insAYVM gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 M916I unknown
ERBB2 M953I no effect - predicted
ERBB2 mutant unknown
ERBB2 mut PIK3CA mut
ERBB2 N1219S no effect - predicted
ERBB2 N319D no effect
ERBB2 N571K no effect - predicted
ERBB2 N813D unknown
ERBB2 N857S gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 negative loss of function
ERBB2 neg ERBB2 pos
ERBB2 over exp no effect HER inhibitor (Pan) HER2 (ERBB2) Antibody HER2 (ERBB2) Immune Cell Therapy HER2 (ERBB2) Vaccine HER2 Inhibitor
ERBB2 over exp PIK3CA H1047R
ERBB2 over exp PIK3CA H1047R SRC over exp
ERBB2 over exp PIK3CA mut
ERBB2 over exp PIK3CA N345T
ERBB2 over exp PIK3CA H1047L
ERBB2 over exp PIK3CA act mut
ERBB2 over exp PIK3CA E542X
ERBB2 over exp PIK3CA E545X
ERBB2 over exp PIK3CA H1047X
ERBB2 P1074L unknown
ERBB2 P1074S gain of function - predicted
ERBB2 P1170A no effect - predicted
ERBB2 P1207A unknown
ERBB2 P1210S no effect - predicted
ERBB2 P122Q no effect - predicted
ERBB2 P1234S no effect - predicted
ERBB2 P197S unknown
ERBB2 P230L unknown
ERBB2 P247S no effect - predicted
ERBB2 P36S no effect - predicted
ERBB2 P391Q no effect - predicted
ERBB2 P416L no effect - predicted
ERBB2 P489L unknown
ERBB2 P489Q unknown
ERBB2 P551L unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 P702L unknown
ERBB2 P761del unknown
ERBB2 P780L unknown
ERBB2 P780_Y781insGSP gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 P885S unknown
ERBB2 P944S unknown
ERBB2 positive unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 pos PIK3CA act mut
ERBB2 pos PIK3CA E545K
ERBB2 pos PIK3CA mut
ERBB2 pos PIK3CA K111N
ERBB2 pos PIK3CA I391M
ERBB2 pos PIK3CA C420R
ERBB2 pos PIK3CA H1047R
ERBB2 pos PIK3CA wild-type
ERBB2 pos PIK3CA N345T
ERBB2 pos PIK3CA H1047L
ERBB2 pos PIK3CA amp
ERBB2 pos PIK3CA E542K
ERBB2 pos PIK3CA E545D
ERBB2 Q679L gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 Q680R no effect
ERBB2 Q709L gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 Q711H no effect - predicted
ERBB2 Q943* unknown
ERBB2 R1006C no effect - predicted
ERBB2 R103Q unknown
ERBB2 R1053M no effect - predicted
ERBB2 R1146W unknown
ERBB2 R1153* unknown
ERBB2 R1153L unknown
ERBB2 R138W no effect - predicted
ERBB2 R143G unknown
ERBB2 R157W unknown
ERBB2 R188C gain of function
ERBB2 R217C unknown
ERBB2 R217H unknown
ERBB2 R226S unknown HER inhibitor (Pan) HER2 Inhibitor
ERBB2 R432W unknown
ERBB2 R456C unknown
ERBB2 R487W no effect - predicted
ERBB2 R545* loss of function - predicted
ERBB2 R647K no effect
ERBB2 R677L gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 R678L unknown
ERBB2 R678Q unknown
ERBB2 R678W gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 R683Q no effect - predicted
ERBB2 R784G unknown
ERBB2 R784H unknown
ERBB2 R849W unknown
ERBB2 R868W loss of function
ERBB2 R896C gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 R897G gain of function - predicted
ERBB2 R897Q no effect - predicted
ERBB2 R966C loss of function
ERBB2 R970W unknown
ERBB2 rearrange unknown
ERBB2 S1002R unknown
ERBB2 S1050L unknown
ERBB2 S250F unknown
ERBB2 S305F no effect - predicted
ERBB2 S310F gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S310F ERBB2 V842I
ERBB2 S310Y gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S423R gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S573L no effect - predicted
ERBB2 S653C gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S656C gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S760A no effect
ERBB2 S779_P780insVGS gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 S783P no effect - predicted
ERBB2 S974A unknown
ERBB2 S974F unknown
ERBB2 T166M unknown
ERBB2 T182I no effect - predicted
ERBB2 T216S gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 T306M no effect - predicted
ERBB2 T496I unknown
ERBB2 T526A gain of function - predicted
ERBB2 T652R no effect - predicted
ERBB2 T686A gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 T686M no effect - predicted
ERBB2 T733I no effect - predicted
ERBB2 T798I no effect - predicted
ERBB2 T798M gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 T862A gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 T862I unknown
ERBB2 T862R gain of function - predicted
ERBB2 V308M unknown
ERBB2 V604_E619del gain of function
ERBB2 V659E gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V697L unknown
ERBB2 V750E loss of function - predicted
ERBB2 V754M gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V773A gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V773L gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V773M unknown
ERBB2 V777A loss of function
ERBB2 V777L gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V777L ERBB2 V842I
ERBB2 V777L PIK3CA H1047R
ERBB2 V777M unknown
ERBB2 V777_G778insG gain of function - predicted HER inhibitor (Pan) HER2 Inhibitor
ERBB2 V782I no effect - predicted
ERBB2 V839G unknown
ERBB2 V842E unknown
ERBB2 V842I unknown
ERBB2 W825* loss of function - predicted
ERBB2 W906* loss of function - predicted
ERBB2 wild-type no effect
ERBB2 Y1248F loss of function - predicted
ERBB2 Y772_A775dup gain of function HER inhibitor (Pan) HER2 Inhibitor
ERBB2 Y803H no effect - predicted
ERBB2 Y803N unknown
ERBB2 Y835F unknown