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|Synonyms||c-erbB-3 | c-erbB3 | ErbB-3 | erbB3-S | FERLK | HER3 | LCCS2 | MDA-BF-1 | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 | VSCN1|
|Gene Description||ERBB3, erb-b2 receptor tyrosine kinase 3, encodes HER3, which is one of three ERBB members of the EGFR receptor tyrosine kinase family, which activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways to promote cell survival and proliferation (PMID: 17471238). Activating Erbb3 mutations have been observed in a several tumor types, including lung and gastric and colon adenocarcinomas (PMID: 31519989) and Erbb3 mutations are also associated with acquired drug resistance (PMID: 31351986).|