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|Synonyms||ER | Era | ESR | ESRA | ESTRR | NR3A1|
|Gene Description||ESR1, estrogen receptor alpha, modulates response to estrogen and is used as a marker to predict response to endocrine therapy in breast cancer patients (PMID: 23542176, PMID: 26183887). ESR1 fusions are recurrent in breast cancer, and mutations in ESR1 have been associated with decreased response to endocrine therapy (PMID: 27372070, PMID: 26183887) in breast cancer (PMID: 31795152).|