Gene Detail

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Gene Symbol FGFR3
Synonyms ACH | CD333 | CEK2 | HSFGFR3EX | JTK4
Gene Description FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).

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Molecular Profile Protein Effect Treatment Approaches
FGFR3 A257V unknown
FGFR3 A341T unknown
FGFR3 A391E gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 A391V no effect - predicted
FGFR3 A452S no effect - predicted
FGFR3 A500T no effect
FGFR3 A634T unknown
FGFR3 act mut gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 amp no effect FGFR Inhibitor (Pan) FGFR3 Antibody FGFR3 Inhibitor
ROS1 fusion ERBB2 amp FGFR3 amp RET amp
FGFR3 C228R gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 C582F no effect
FGFR3 D222N unknown
FGFR3 D617G loss of function - predicted
FGFR3 D641G gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 D641N gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 D646Y no effect
FGFR3 D762H no effect - predicted
FGFR3 D764H unknown
FGFR3 D785N no effect - predicted
FGFR3 D786N gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 D788N unknown
FGFR3 dec exp no effect
FGFR3 dec exp FGFR3 wild-type HRAS G12V
FGFR3 E216K unknown
FGFR3 E322K unknown
FGFR3 E360Q loss of function - predicted
FGFR3 E456K unknown
FGFR3 E466K no effect
FGFR3 E627D no effect
FGFR3 E686K unknown
FGFR3 F384L no effect
FGFR3 F386L unknown
FGFR3 - BAIAP2L1 gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 - ELAVL3 unknown
FGFR3 - TACC3 gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor U0126
FGFR2 fusion FGFR3 - TACC3
FGFR2 - CCDC6 FGFR3 - TACC3
FGFR3 fusion unknown
FGFR3 G197S unknown
FGFR3 G235D unknown
FGFR3 G346E no effect - predicted
FGFR3 G370C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G372C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G375C gain of function - predicted
FGFR3 G380R gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G382D gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G382D FGFR3 over exp
FGFR3 G382R gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G384D gain of function - predicted
FGFR3 G384D FGFR3 over exp
FGFR3 G637W loss of function - predicted
FGFR3 G65R unknown
FGFR3 G697C no effect
FGFR3 G710D unknown
FGFR3 H274Y no effect - predicted
FGFR3 H349Y unknown
FGFR3 H643D no effect
FGFR3 I376C unknown
FGFR3 I538F no effect
FGFR3 I538V gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 inact mut loss of function
FGFR3 K319del no effect - predicted
FGFR3 K413N unknown
FGFR3 K508M loss of function
FGFR3 K650E gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650E HRAS K117E
FGFR3 K650E FGFR3 over exp HRAS K117E
FGFR3 K650M gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650N gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650Q gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650T gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K652E gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K715M unknown
FGFR3 L385M unknown
FGFR3 L608V unknown
FGFR3 V555M FGFR3 L608V
FGFR3 L645V unknown
FGFR3 L794fs unknown
FGFR3 L794R unknown
FGFR3 M528I gain of function
FGFR3 mutant unknown
FGFR3 mut FGFR3 over exp
FGFR3 N540K gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 N540S gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 N540T unknown
FGFR3 N540V unknown
FGFR3 N653H no effect
FGFR3 over exp no effect FGFR Inhibitor (Pan) FGFR3 Antibody FGFR3 Inhibitor
FGFR3 Y373C FGFR3 over exp
FGFR3 S249C FGFR3 over exp
FGFR3 P253_I254insHIA unknown
FGFR3 P283S unknown
FGFR3 P402S no effect - predicted
FGFR3 P572A no effect
FGFR3 P795A unknown
FGFR3 P91L unknown
FGFR3 positive unknown
FGFR2 pos FGFR3 pos
FGFR3 Q209H unknown
FGFR3 Q256R unknown
FGFR3 R112Q unknown
FGFR3 R124W gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R200C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R248C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R248H unknown
FGFR3 R399C no effect - predicted
FGFR3 R421Q unknown
FGFR3 R603Q unknown
FGFR3 R640W unknown
FGFR3 R669G gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R669Q gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R805Q no effect - predicted
FGFR3 rearrange unknown
FGFR3 S131L unknown
FGFR3 S187Y no effect - predicted
FGFR3 S249C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 S351C loss of function - predicted
FGFR3 S371C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 S400fs loss of function - predicted
FGFR3 S433C unknown
FGFR3 S679F unknown
FGFR3 S780C no effect - predicted
FGFR3 T394M no effect - predicted
FGFR3 T79S unknown
FGFR3 V172I loss of function - predicted
FGFR3 V306I unknown
FGFR3 V329A unknown
FGFR3 V390M no effect - predicted
FGFR3 V50I gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 V555L unknown
FGFR3 V555M gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 V630M no effect
FGFR3 V642M no effect - predicted
FGFR3 V677I no effect
FGFR3 V700A unknown
FGFR3 V788M gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 wild-type no effect
FGFR3 Y241C unknown
FGFR3 Y373C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
AKT1 E17K FGFR3 Y373C
FGFR3 Y375C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 Y379C unknown
FGFR3 Y647C gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor