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Gene Symbol IKZF3
Synonyms AIO | AIOLOS | IMD84 | ZNFN1A3
Gene Description IKZF3, IKAROS family zinc finger 3, encodes the transcription factor Aiolos, which is involved in regulating gene expression and chromatin remodeling to control lymphocyte proliferation, differentiation, maturation, and survival (PMID: 10369681, PMID: 11997672, PMID: 21477865). IKZF3 mutations have been identified in chronic myeloid leukemia (PMID: 24212482), and overexpression of IKZF3 has been observed in chronic lymphocytic leukemia (PMID: 18184862, PMID: 19016725), multiple myeloma (PMID: 26823144), and lung cancer (PMID: 27308319).
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