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|Synonyms||HIAA0929 | MINT | RBM15C | SHARP|
|Gene Description||SPEN, spen family transcriptional repressor, acts acts as a negative transcriptional regulator of ESR1 (PMID: 26297734), plays a hormone independent role in primary cilia formation and cell migration (PMID: 28877752), and promotes beta-catenin pathway activity (PMID: 17234755). SPEN mutations and copy number loss have been identified in ER-positive breast cancer (PMID: 26297734), and increased expression levels have been reported in colorectal cancer (PMID: 17234755).|