Gene Detail


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Gene Symbol MPRIP
Synonyms M-RIP | MRIP | p116Rip | RHOIP3 | RIP3
Gene Description MPRIP, myosin phosphatase Rho interacting protein, regulates cytoskeleton dynamics by targeting myosin phosphatase for myosin light chain phosphorylation (PMID: 16257966). MPRIP-BRAF fusions have been identified in pancreatic cancer and lung cancer (PMID: 26314551, PMID: 24162815), an MPRIP-ALK fusion has been reported in non-small cell lung cancer (PMID: 31235041), and an MPRIP-PDGFRB fusion has been reported in eosinophilia-associated myeloproliferative neoplasm (PMID: 26355392).
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