Gene Detail


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Gene Symbol ICOSLG
Synonyms B7-H2 | B7h | B7H2 | B7RP-1 | B7RP1 | CD275 | GL50 | ICOS-L | ICOSL | LICOS
Gene Description ICOSLG, inducible T cell costimulator ligand, encodes a member of the B7 family of ligands, which triggers T cell proliferation and cytokine production upon binding to the T cell receptor, ICOS (PMID: 11973139, PMID: 10549624). Expression of ICOSLG has been identified in myeloma and acute myeloid leukemia (PMID: 19188146, PMID: 16115907), and overexpression of ICOSLG has been observed in esophageal squamous cell carcinoma (PMID: 29147607).
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