Gene Detail


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Gene Symbol FOSB
Synonyms AP-1 | G0S3 | GOS3 | GOSB
Gene Description FOSB, FosB proto-oncogene, AP-1 transcription factor subunit, encodes a leucine zipper transcription factor of the Fos family that plays a role in mediating cell proliferation and differentiation (PMID: 11402335, PMID: 15564374), and is involved in the neural circuitry related to reward (PMID: 23319622, PMID: 17560044). FOSB expression is decreased in pancreatic cancer (PMID: 20571966), and FOSB fusions have been identified in hemangioendothelioma (PMID: 24374978, PMID: 31243110).
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