Gene Detail

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Gene Symbol ABL1
Synonyms ABL | BCR-ABL | bcr/abl | c-ABL | c-ABL1 | CHDSKM | JTK7 | p150 | v-abl
Gene Description ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, plays a role in regulation of cell growth through ERK5, Rac/JNK, and Stat1/3 pathways (PMID: 10373409). Fusion proteins of BCR-ABL1 resulting in constitutive kinase activity have been reported in various cancers (PMID: 18851712, PMID: 30125955) and a number of Abl1 mutations in the context of BCR-ABL1 have been demonstrated to confer drug resistance (PMID: 24456693).

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Molecular Profile Protein Effect Treatment Approaches
ABL1 A287V unknown
ABL1 A337T gain of function
ABL1 A337V gain of function
ABL1 A344P gain of function - predicted
ABL1 A356T gain of function
ABL1 A380T unknown
ABL1 A397P unknown
ABL1 act mut gain of function
ABL1 amp no effect
ABL1 C330G unknown
ABL1 C475W unknown
ABL1 D276G gain of function - predicted
ABL1 D363G unknown
ABL1 E1085K unknown
ABL1 E255K unknown
ABL1 E255V unknown
ABL1 E275D unknown
ABL1 E279K unknown
ABL1 E279V unknown
ABL1 E279W unknown
ABL1 E281K unknown
ABL1 E282D unknown
ABL1 E292L unknown
ABL1 E308* loss of function - predicted
ABL1 E355A unknown
ABL1 E355G unknown
ABL1 E450G unknown
ABL1 E453K unknown
ABL1 E459K unknown
ABL1 E507G unknown
ABL1 F311I unknown
ABL1 F311L unknown
ABL1 F317C unknown
ABL1 F317I unknown
ABL1 F317L unknown
ABL1 F317R unknown
ABL1 F317V unknown
ABL1 F359C unknown
ABL1 F359I unknown
ABL1 F359V unknown
ABL1 F486S unknown
ABL1 fusion unknown
ABL1 G250E unknown
ABL1 G250H unknown
ABL1 G250R unknown
ABL1 G250R ABL1 G251D
ABL1 G250W unknown
ABL1 G251D unknown
ABL1 G251E unknown
ABL1 G321L gain of function - predicted
ABL1 G463S unknown
ABL1 H295dup unknown
ABL1 H396P unknown
ABL1 H396R unknown
ABL1 I242M unknown
ABL1 I432M unknown
ABL1 I502L unknown
ABL1 inact mut loss of function
ABL1 K262N unknown
ABL1 K294E unknown
ABL1 K357dup unknown
ABL1 K596* loss of function - predicted
ABL1 K609del unknown
ABL1 L248R unknown
ABL1 L248V unknown
ABL1 L298V unknown
ABL1 L302H unknown
ABL1 L384M unknown
ABL1 L387M unknown
ABL1 M237R unknown
ABL1 M237V unknown
ABL1 M244V unknown
ABL1 M343T unknown
ABL1 M351T loss of function - predicted
ABL1 M388L unknown
ABL1 M437I unknown
ABL1 mutant unknown
ABL1 N368S unknown
ABL1 over exp no effect
ABL1 P223S unknown
ABL1 P230E unknown
ABL1 P309fs loss of function - predicted
ABL1 P310L unknown
ABL1 P465S gain of function
ABL1 P918S unknown
ABL1 P980L unknown
ABL1 Q252H unknown
ABL1 Q346L unknown
ABL1 R239C unknown
ABL1 R332W gain of function
ABL1 T315I ABL1 R332W
ABL1 R362fs loss of function - predicted
ABL1 R362T unknown
ABL1 R386M unknown
ABL1 R577* loss of function - predicted
ABL1 R639* loss of function - predicted
ABL1 rearrange unknown ABL Inhibitor (pan)
ABL1 S417Y unknown
ABL1 S972L unknown
ABL1 T277I unknown
ABL1 T315A unknown
ABL1 T315C unknown
ABL1 T315D unknown
ABL1 T315E unknown
ABL1 T315F unknown
ABL1 T315G unknown
ABL1 T315H unknown
ABL1 T315I unknown
ABL1 T315K unknown
ABL1 T315L unknown
ABL1 T315M unknown
ABL1 T315N unknown
ABL1 T315P unknown
ABL1 T315Q unknown
ABL1 T315R unknown
ABL1 T315S unknown
ABL1 T315V unknown
ABL1 T315W unknown
ABL1 T315Y unknown
ABL1 V289F unknown
ABL1 V299L unknown
ABL1 V379I unknown
ABL1 V422I unknown
ABL1 V468F gain of function
ABL1 wild-type no effect
ABL1 Y226C gain of function
ABL1 Y245C gain of function
ABL1 Y253F unknown
ABL1 Y253H unknown
ABL1 Y440C unknown
ABL1 Y456C unknown