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Gene Symbol RICTOR
Synonyms AVO3 | hAVO3 | PIA
Gene Description RICTOR, RPTOR independent companion of MTOR complex 2, is a component of the mTORC2 complex, which regulates cell survival and tumorgenesis (PMID: 25450580) through the PI3K-AKT pathway (PMID: 32041519). Amplification and/or overexpression of Rictor have been identified in a variety of cancers (PMID: 29455662), including small cell lung cancer, colorectal cancer, and esophageal cancer (PMID: 31740232), where it may promote resistance to tyrosine kinase inhibitors (PMID: 32041519).


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