Gene Detail

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Gene Symbol

SETBP1

Synonyms

MRD29 | SEB

Gene Description

SETBP1, SET binding protein 1, is part of a multiprotein epigenetic complex, which regulates target genes including MECOM (PMID: 29875417) and the tumor suppressor protein phosphatase type 2a (PP2A) (PMID: 11231286). Overexpression and gain of function mutations in Setbp1 have been linked to a variety of myeloproliferative diseases with worse clinical outcomes (PMID: 23892662, PMID: 28447248) and loss and gain of function mutations and have been reported in leukemia (PMID: 29875417, PMID: 28346496).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
26040	18	18q12.3	NM_015559	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 90
Category Variants 3
Molecular Profiles 90
Evidence 3
Clinical Trials 1