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|Synonyms||DCML | IMD21 | MONOMAC | NFE1B|
|Gene Description||GATA2, GATA binding protein 2, is a zinc-finger transcription factor that plays a central role in regulating the proliferation, differentiation, and survival of hematopoietic stem cells (PMID: 22192845, PMID: 32205587). Mutations in GATA2 are associated with myelodysplastic syndrome and leukemia (PMID: 22192845, PMID: 31785092) and decreased expression has been associated with melanoma progression (PMID: 29156497).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|GATA2 mutant||acute myeloid leukemia||not applicable||N/A||Clinical Study||Prognostic||In multiple clinical studies, GATA2 germline mutations were shown to be a risk factor for the development of acute myeloid leukemia following myelodysplastic syndrome (PMID: 21892162, PMID: 22271902, PMID: 22147895, PMID: 22533337).||22533337 22271902 22147895 21892162|
|GATA2 mutant||myelodysplastic syndrome||not applicable||N/A||Guideline||Prognostic||GATA2 frameshift, nonsense, or splice site mutations, or missense mutations in codons 349-398 are associated with poor prognosis in patients with myelodysplastic syndrome (NCCN.org).||detail...|
|CEBPA mut GATA2 mut||acute myeloid leukemia||not applicable||N/A||Clinical Study||Prognostic||In clinical analyses, mutations in GATA2 were associated with better overall survival in patients with cytogenetically normal acute myeloid leukemia (CN-AML) harboring biallelic CEBPA gene mutations (PMID: 22814295, PMID: 23521373, PMID: 25241285).||25241285 22814295 23521373|