Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | FBXO4 | ||||||||||
| Synonyms | FBX4 | ||||||||||
| Gene Description | FBXO4, F-box protein 4, is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PMID: 18598945), cyclin D1 (CCND1) and telomeric-repeat factor 1 (TRF1) (PMID: 29142209). FBXO4 is the E3 ligase for CCND1 and inactivating mutations in FBXO4 may cause CCND1 overexpression, leading to oncogenic transformation (PMID: 18598945) in esophageal squamous cell carcinoma and melanoma (PMID: 29142209). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
