Gene Detail

Gene Symbol FBXO4
Synonyms FBX4
Gene Description FBXO4, F-box only protein 4, is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO4 is the E3 ligase for CCND1 and inactivating mutations in FBXO4 may cause CCND1 overexpression, leading to oncogenic transformation (PMID: 18598945).
Entrez Id 26272
Chromosome 5
Map Location 5p13.1
Canonical Transcript NM_012176

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