Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol MLH3
Synonyms HNPCC7
Gene Description MLH3, mutL homolog 3, is a DNA mismatch repair gene that dimerizes with MLH1 and localizes to centrosomes (PMID: 24333356, PMID: 25116689) and may play a role in triplet repeat DNA expansions (PMID: 32015124). MLH3 mutations have been associated with cervical squamous cell carcinoma (PMID: 24759751) and germline inactivating mutations have been reported in attenuated adenomatous polyposis (PMID: 30573798).
Additional content available in CKB BOOST