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|Synonyms||ACLS | GCPS | GLI3-190 | GLI3FL | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIV|
|Gene Description||GLI3, GLI family zinc finger 3, is a transcription factor acting in the Sonic Hedgehog signaling pathway in developmental regulation (PMID: 11001584) and functions as a transcriptional repressor or activator depending on downstream processing of the GLI3 mRNA or protein (PMID: 30272273). GLI3 overexpression is associated with resistance to cyclopamine in pancreatic adenocarcinoma (PMID: 20814245), while knockdown of GLI3 expression in oral squamous cell carcinoma cells promotes proliferation (PMID: 30272273) and decreased GLI3 expression has been observed in acute myeloid leukemia (PMID: 28487292).|