Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||FBH | FBH2 | FHH2 | GNA-11 | HHC2 | HYPOC2|
|Gene Description||GNA11, G protein subunit alpha 11, is a guanine nucleotide-binding protein (G protein) subunit, which is activated following ligand binding to G-protein coupled receptors and functions in cell signaling (PMID: 27148356). GNA11 hotspot mutations impair intrinsic Gna11 GTPase activity, resulting in constitutive pathway activation and are common in uveal melanoma (PMID: 23640210, PMID: 27148356, PMID: 29209985).|