Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at :

Gene Symbol GNAS
Synonyms AHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | NESP | PITA3 | POH | SCG6 | SgVI
Gene Description GNAS, GNAS complex locus, is a GTPase that is activated upon ligand binding of a G-protein coupled receptor, and is involved in mediating hormone response (PMID: 23640210, PMID: 25851935). Hotspot mutations impair Gnas GTPase activity, resulting in constitutive pathway activation and are common in a variety of tumor types (PMID: 23640210).


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
GNAS act mut unknown
GNAS amp no effect
GNAS D173N loss of function
GNAS G801R unknown
GNAS inact mut loss of function
GNAS K338R unknown
GNAS mutant unknown
GNAS Q227E unknown
GNAS Q227H unknown
GNAS Q227K unknown
GNAS Q227L loss of function
GNAS Q227R loss of function - predicted
GNAS Q227X unknown
GNAS R201C loss of function
GNAS R201G unknown
GNAS R201H loss of function
GNAS R201L unknown
GNAS R201S unknown
GNAS R265H loss of function
GNAS R6P no effect - predicted
GNAS T225P no effect - predicted
GNAS wild-type no effect