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Gene Symbol TRIB2
Synonyms C5FW | GS3955 | TRB2
Gene Description TRIB2, tribbles pseudokinase 2, lacks kinase activity and plays a role in regulating protein stability through E3 ubiquitin ligases and also regulates AKT signaling (PMID: 30254057). Overexpression of Trib2 has been observed in malignant melanoma (PMID: 20208562), glioblastome (PMID: 31318172), colon cancer, and pancreatic cancer (PMID: 28276427), and may contribute to drug resistance to PIK3 inhibitors (PMID: 28276427) and cisplatin (PMID: 29312632).


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