Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||C5FW | GS3955 | TRB2|
|Gene Description||TRIB2, tribbles homolog 2, is a pseudokinase, without kinase activity that plays a role in regulating protein stability through E3 ubiquitin ligases and also regulates AKT signaling (PMID: 30254057). Overexpression of Trib2 has been observed in malignant melanoma (PMID: 20208562), colon cancer, and pancreatic cancer (PMID: 28276427) and may contribute to drug resistance to PIK3 inhibitors (PMID: 28276427) and cisplatin (PMID: 29312632).|