Gene Detail
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| Gene Symbol | TRIB2 | ||||||||||
| Synonyms | C5FW | GS3955 | TRB2 | ||||||||||
| Gene Description | TRIB2, tribbles pseudokinase 2, lacks kinase activity and plays a role in regulating protein stability through E3 ubiquitin ligases and also regulates AKT signaling (PMID: 30254057). Overexpression of Trib2 has been observed in malignant melanoma (PMID: 20208562), glioblastome (PMID: 31318172), colon cancer, and pancreatic cancer (PMID: 28276427), and may contribute to drug resistance to PIK3 inhibitors (PMID: 28276427) and cisplatin (PMID: 29312632). | ||||||||||
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