Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | SETD2 | ||||||||||
| Synonyms | HBP231 | HIF-1 | HIP-1 | HSPC069 | HYPB | KMT3A | LLS | MRD70 | p231HBP | RAPAS | SET2 | ||||||||||
| Gene Description | SETD2, histone-lysine N-methyltransferase SETD2, regulates chromatin structure through H3K36 to influence gene transcription (PMID: 28159833; PMID: 28386724) and plays a role in genomic stability (PMID: 31747945). Loss of function and decreased expression of Setd2 has been demonstrated in clear cell renal cell carcinoma (PMID: 28260718), breast cancer (PMID: 20501857) and lung cancer (PMID: 28202515). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
