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|Synonyms||HBP231 | HIF-1 | HIP-1 | HSPC069 | HYPB | KMT3A | LLS | p231HBP | SET2|
|Gene Description||SETD2, histone-lysine N-methyltransferase SETD2, regulates chromatin structure through H3K36 to influence gene transcription (PMID: 28159833; PMID: 28386724) and plays a role in genomic stability (PMID: 31747945). Loss of function and decreased expression of Setd2 has been demonstrated in clear cell renal cell carcinoma (PMID: 28260718), breast cancer (PMID: 20501857) and lung cancer (PMID: 28202515).|