Gene Detail

Gene Symbol CD274
Synonyms B7-H | B7H1 | hPD-L1 | PD-L1 | PDCD1L1 | PDCD1LG1 | PDL1
Gene Description CD274, CD274 molecule, encodes for an immunomodulatory ligand (PD-L1), which once bound to its receptor, PD-1, results in inhibition of T-cell activation (PMID: 24551119). CD274 overexpression has been observed across multiple tumor types, which has been associated with CD274 amplification, specifically in Hodgkin's lymphoma (PMID: 20628145).
Entrez Id 29126
Chromosome 9
Map Location 9p24.1
Canonical Transcript NM_014143

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