Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | MST131 | MSTP131 | NDF | NRG1-IT2 | SMDF|
|Gene Description||NRG1, neuregulin 1, encodes for a ligand that can bind to Erbb3 (Her3) and Erbb4, which upon binding forms dimers with other ERBB (HER) family receptors, which may result in activation of downstream signaling pathways (PMID: 10880430). NRG1 forms fusions with multiple gene partners (PMID: 30988082) and have been identified in a variety of tumor types, including lung cancer (PMID: 25501131, PMID: 31382039) and pancreatic cancer (PMID: 31068372).|