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Gene Symbol APC
Synonyms BTPS2 | DESMD | DP2 | DP2.5 | DP3 | GS | PPP1R46
Gene Description APC, adenomatous polyposis coli, is a tumor suppressor (PMID: 30562755) and multi-domain protein regulating numerous cellular functions through interaction with beta-catenin and subsequent inhibition of Wnt signalling (PMID: 10959075). APC germline mutations are associated with familial adenomatous polyposis (PMID: 30562755) and somatic mutations with colon, endometrial, NSCLC, and breast cancers (PMID: 27283171).
ACMG Incidental List v2.0:
Yes, Adenomatous polyposis coli (PMID: 27854360)

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
inact mut unknown loss of function APC inact mut indicates that this variant results in a loss of function of the Apc protein. However, the specific amino acid change has not been identified.
mutant unknown unknown APC mutant indicates an unspecified mutation in the APC gene.
A1296fs frameshift loss of function - predicted APC A1296fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1296 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1296fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1296fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1305fs frameshift loss of function - predicted APC A1305fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1305 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1305fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1305fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1316fs frameshift loss of function - predicted APC A1316fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1316 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1316fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1316fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1325fs frameshift loss of function - predicted APC A1325fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1325 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1325fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1325fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1351fs frameshift loss of function - predicted APC A1351fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1351 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1351fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1351fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1402fs frameshift loss of function - predicted APC A1402fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1402 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1402fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1402fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1446fs frameshift loss of function - predicted APC A1446fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1446 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1446fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1446fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1470fs frameshift loss of function - predicted APC A1470fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1470 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1470fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1470fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1471fs frameshift loss of function - predicted APC A1471fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1471 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1471fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1471fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1475fs frameshift loss of function - predicted APC A1475fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1475 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1475fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1475fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A1485fs frameshift loss of function - predicted APC A1485fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1485 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1485fs has not been characterized, however Apc truncation mutants downstream of T1485 are inactivating (PMID: 18199528) thus, A1485fs is predicted to lead to a loss of Apc protein function.
A1492fs frameshift loss of function - predicted APC A1492fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1492 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1492fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), A1492fs is predicted to reduce the ability of Apc to regulate beta-catenin.
A928fs frameshift loss of function - predicted APC A928fs results in a change in the amino acid sequence of the Apc protein beginning at aa 928 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A928fs has not been characterized, however Apc truncation mutants downstream of A928 are inactivating (PMID: 18199528) thus, A928fs is predicted to lead to a loss of Apc protein function.
C1274fs frameshift loss of function - predicted APC C1274fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1274 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1274fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), C1274fs is predicted to reduce the ability of Apc to regulate beta-catenin.
C1289fs frameshift loss of function - predicted APC C1289fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1289 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1289fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), C1289fs is predicted to reduce the ability of Apc to regulate beta-catenin.
C1387fs frameshift loss of function - predicted APC C1387fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1387 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1387fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), C1387fs is predicted to reduce the ability of Apc to regulate beta-catenin.
C1578fs frameshift unknown APC C1578fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1578 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1578fs has been identified in sequencing studies (PMID: 20102718), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Jul 2020).
D1297fs frameshift loss of function - predicted APC D1297fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1297 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1297fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1297fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1318fs frameshift loss of function - predicted APC D1318fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1318 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1318fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1318fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1394fs frameshift loss of function - predicted APC D1394fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1394 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1394fs has not been characterized, however Apc truncation mutants downstream of D1394 are inactivating (PMID: 18199528) thus, D1394fs is predicted to lead to a loss of Apc protein function.
D1422fs frameshift loss of function - predicted APC D1422fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1422 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1422fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1422fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1425fs frameshift loss of function - predicted APC D1425fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1425 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1425fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1425fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1484fs frameshift loss of function - predicted APC D1484fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1484 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1484fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1484fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1486fs frameshift loss of function - predicted APC D1486fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1486 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1486fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), D1486fs is predicted to reduce the ability of Apc to regulate beta-catenin.
D1636fs frameshift unknown APC D1636fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1817 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1636fs has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, May 2020).
E1306fs frameshift loss of function - predicted APC E1306fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1306 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1306fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), E1306fs is predicted to reduce the ability of Apc to regulate beta-catenin.
E1309fs frameshift loss of function - predicted APC E1309fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1309 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1309fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), E1309fs is predicted to reduce the ability of Apc to regulate beta-catenin.
E1464fs frameshift loss of function - predicted APC E1464fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1464 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1464fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), E1464fs is predicted to reduce the ability of Apc to regulate beta-catenin.
E1494fs frameshift loss of function - predicted APC E1494fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1494 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1494fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), E1494fs is predicted to reduce the ability of Apc to regulate beta-catenin.
E1536fs frameshift loss of function - predicted APC E1536fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1536 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1536fs has not been characterized however, due to the effects of other truncation mutations downstream of 1536 (PMID: 18199528, PMID: 10346819), E1536fs is predicted to lead to a loss of Apc protein function.
E1554fs frameshift loss of function - predicted APC E1554fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1554 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1554fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), E1554fs is predicted to reduce the ability of Apc to regulate beta-catenin.
E582fs frameshift loss of function - predicted APC E582fs results in a change in the amino acid sequence of the Apc protein beginning at aa 582 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E582fs has not been characterized, however, Apc truncation mutants downstream of E582 are inactivating (PMID: 18199528) and therefore, is predicted to lead to a loss of Apc protein function.
F1354fs frameshift loss of function - predicted APC F1354fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1354 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). F1354fs has not been characterized, however, Apc truncation mutants downstream of F1354 are inactivating (PMID: 18199528) thus, F1354fs is predicted to lead to a loss of Apc protein function.
F1491fs frameshift loss of function - predicted APC F1491fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1491 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). F1491fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), F1491fs is predicted to reduce the ability of Apc to regulate beta-catenin.
G1312fs frameshift loss of function - predicted APC G1312fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1312 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). G1312fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), G1312fs is predicted to reduce the ability of Apc to regulate beta-catenin.
G1357fs frameshift loss of function - predicted APC G1357fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1357 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). G1357fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), G1357fs is predicted to reduce the ability of Apc to regulate beta-catenin.
H1375fs frameshift loss of function - predicted APC H1375fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1375 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). H1375fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), H1375fs is predicted to reduce the ability of Apc to regulate beta-catenin.
H1490fs frameshift loss of function - predicted APC H1490fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1490 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). H1490fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), H1490fs is predicted to reduce the ability of Apc to regulate beta-catenin.
I1164fs frameshift loss of function - predicted APC I1164fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1164 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1164fs has not been characterized, however Apc truncation mutants downstream of I1164 are inactivating (PMID: 18199528, PMID: 10346819), thus, I1164fs is predicted to lead to a loss of Apc protein function.
I1307fs frameshift loss of function - predicted APC I1307fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1307 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1307fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), I1307fs is predicted to reduce the ability of Apc to regulate beta-catenin.
I1311fs frameshift loss of function - predicted APC I1311fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1311 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1311fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), I1311fs is predicted to reduce the ability of Apc to regulate beta-catenin.
I1557fs frameshift loss of function - predicted APC I1557fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1557 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1557fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), I1557fs is predicted to reduce the ability of Apc to regulate beta-catenin.
I606fs frameshift loss of function - predicted APC I606fs results in a change in the amino acid sequence of the Apc protein beginning at aa 606 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I606fs has not been characterized, however, Apc truncation mutants downstream of I606 are inactivating (PMID: 18199528) thus, I606fs is predicted to lead to a loss of Apc protein function.
K1310fs frameshift loss of function - predicted APC K1310fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1310 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1310fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), K1310fs is predicted to reduce the ability of Apc to regulate beta-catenin.
K1449fs frameshift loss of function - predicted APC K1449fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1449 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1449fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), K1449fs is predicted to reduce the ability of Apc to regulate beta-catenin.
K1462fs frameshift loss of function - predicted APC K1462fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1462 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1462fs has not been characterized, however Apc truncation mutants downstream of K1462 are inactivating (PMID: 18199528) thus, K1462fs is predicted to lead to a loss of Apc protein function.
K1555fs frameshift loss of function - predicted APC K1555fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1555 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1555fs has not been characterized, however Apc truncation mutants downstream of K1555 are inactivating (PMID: 18199528) thus, K1555fs is predicted to lead to a loss of Apc protein function.
K1817fs frameshift unknown APC K1817fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1817 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1817fs has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, Jul 2020).
L1302fs frameshift loss of function - predicted APC L1302fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1302 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1302fs has not been characterized, however, due to the effects of truncations downstream of 1302 (PMID: 10346819, PMID: 18199528), is predicted to lead to a loss of Apc protein function.
L1488fs frameshift loss of function - predicted APC L1488fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1488 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1488fs has not been characterized, however Apc truncation mutants downstream of L1488 are inactivating (PMID: 18199528) thus, L1488fs is predicted to lead to a loss of Apc protein function.
L1489fs frameshift loss of function - predicted APC L1489fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1489 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1489fs has not been characterized, however Apc truncation mutants downstream of L1489 are inactivating (PMID: 18199528) thus, L1489fs is predicted to lead to a loss of Apc protein function.
M1431fs frameshift loss of function - predicted APC M1431fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1431 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). M1431fs has not been characterized, however Apc truncation mutants downstream of M1431 are inactivating (PMID: 18199528) thus, M1431fs is predicted to lead to a loss of Apc protein function.
N1300fs frameshift loss of function - predicted APC N1300fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1300 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1300fs has not been characterized, however Apc truncation mutants downstream of N1300 are inactivating (PMID: 18199528) thus, N1300fs is predicted to lead to a loss of Apc protein function.
N1455fs frameshift loss of function - predicted APC N1455fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1455 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1455fs has not been characterized, however Apc truncation mutants downstream of N1455 are inactivating (PMID: 18199528) thus, N1455fs is predicted to lead to a loss of Apc protein function.
N1819fs frameshift unknown APC N1819fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1819 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1819fs has been identified in the scientific literature (PMID: 28179481), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Jul 2020).
N741fs frameshift loss of function - predicted APC N741fs results in a change in the amino acid sequence of the Apc protein beginning at aa 741 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N741fs has not been characterized, however Apc truncation mutants downstream of N741 are inactivating (PMID: 18199528) thus, N741fs is predicted to lead to a loss of Apc protein function.
N869fs frameshift loss of function - predicted APC N869fs results in a change in the amino acid sequence of the Apc protein beginning at aa 869 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N869fs has not been characterized, however Apc truncation mutants downstream of N869 are inactivating (PMID: 18199528) thus, N869fs is predicted to lead to a loss of Apc protein function.
P1319fs frameshift loss of function - predicted APC P1319fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1319 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1319fs has not been characterized, however Apc truncation mutants downstream of P1319 are inactivating (PMID: 18199528) thus, P1319fs is predicted to lead to a loss of Apc protein function.
P1361fs frameshift loss of function - predicted APC P1361fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1361 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1361fs has not been characterized, however Apc truncation mutants downstream of P1361 are inactivating (PMID: 18199528) thus, P1361fs is predicted to lead to a loss of Apc protein function.
P1372fs frameshift loss of function - predicted APC P1372fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1372 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1372fs has not been characterized, however Apc truncation mutants downstream of P1372 are inactivating (PMID: 18199528) thus, P1372fs is predicted to lead to a loss of Apc protein function.
P1373fs frameshift loss of function - predicted APC P1373fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1373 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1373fs has not been characterized, however Apc truncation mutants downstream of P1373 are inactivating (PMID: 18199528) thus, P1373fs is predicted to lead to a loss of Apc protein function.
P1439fs frameshift loss of function - predicted APC P1439fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1439 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1439fs has not been characterized, however, Apc truncation mutants downstream of P1439 are inactivating (PMID: 18199528) and thus, P1439fs is predicted to lead to a loss of Apc protein function.
P1440fs frameshift loss of function - predicted APC P1440fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1440 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1440fs has not been characterized, however Apc truncation mutants downstream of P1440 are inactivating (PMID: 18199528) thus, P1440fs is predicted to lead to a loss of Apc protein function.
P1443fs frameshift loss of function - predicted APC P1443fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1443 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1443fs has not been characterized, however Apc truncation mutants downstream of P1443 are inactivating (PMID: 18199528) thus, P1443fs is predicted to lead to a loss of Apc protein function.
P1453fs frameshift loss of function - predicted APC P1453fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1453 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1453fs has not been characterized, however Apc truncation mutants downstream of P1453 are inactivating (PMID: 18199528) thus, P1453fs is predicted to lead to a loss of Apc protein function.
P1458fs frameshift loss of function - predicted APC P1458fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1458 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1458fs has not been characterized, however Apc truncation mutants downstream of P1458 are inactivating (PMID: 18199528) thus, P1458fs is predicted to lead to a loss of Apc protein function.
P1483fs frameshift loss of function - predicted APC P1483fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1483 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1483fs has not been characterized, however Apc truncation mutants downstream of P1483 are inactivating (PMID: 18199528) thus, P1483fs is predicted to lead to a loss of Apc protein function.
P1497fs frameshift loss of function - predicted APC P1497fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1497 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1497fs has not been characterized, however Apc truncation mutants downstream of P1497 are inactivating (PMID: 18199528) thus, P1497fs is predicted to lead to a loss of Apc protein function.
Q1294fs frameshift loss of function - predicted APC Q1294fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1294 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1294fs has not been characterized, however Apc truncation mutants downstream of Q1294 are inactivating (PMID: 18199528) thus, Q1294fs is predicted to lead to a loss of Apc protein function.
Q1303fs frameshift loss of function - predicted APC Q1303fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1303 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1303fs has not been characterized, however Apc truncation mutants downstream of Q1303 are inactivating (PMID: 18199528) thus, Q1303fs is predicted to lead to a loss of Apc protein function.
Q1378fs frameshift loss of function - predicted APC Q1378fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1378 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). APC Q1378fs has not been characterized, however Apc truncation mutants downstream of Q1378 are inactivating (PMID: 18199528) thus, Q1378fs is predicted to lead to a loss of Apc protein function.
Q1429fs frameshift loss of function - predicted APC Q1429fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1429 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1429fs has not been characterized, however Apc truncation mutants downstream of Q1429 are inactivating (PMID: 18199528) thus, Q1429fs is predicted to lead to a loss of Apc protein function.
R1314fs frameshift loss of function - predicted APC R1314fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1314 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). APC R1314fs has not been characterized, however Apc truncation mutants downstream of R1314 are inactivating (PMID: 18199528) thus, R1314fs is predicted to lead to a loss of Apc protein function.
R1348fs frameshift loss of function - predicted APC R1348fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1348 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). R1348fs has not been characterized, however Apc truncation mutants downstream of R1348 are inactivating (PMID: 18199528) thus, R1348fs is predicted to lead to a loss of Apc protein function.
R1435fs frameshift loss of function - predicted APC R1435fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1435 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). R1435fs has not been characterized, however Apc truncation mutants downstream of R1435 are inactivating (PMID: 18199528) thus, R1435fs is predicted to lead to a loss of Apc protein function.
S1315fs frameshift loss of function - predicted APC S1315fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1315 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1315fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1315fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1355fs frameshift loss of function - predicted APC S1355fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1355 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1355fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1355fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1356fs frameshift loss of function - predicted APC S1356fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1356 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1356fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1356fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1364fs frameshift loss of function - predicted APC S1364fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1364 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1364fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1364fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1411fs frameshift loss of function - predicted APC S1411fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1411 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1411fs has not been characterized, however, due to the effects of Apc truncation mutations downstream of S1411 (PMID: 10346819, PMID: 18199528), S1411fs is predicted to result in a loss in Apc protein function.
S1436fs frameshift loss of function - predicted APC S1436fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1436 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1436fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1436fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1465fs frameshift loss of function - predicted APC S1465fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1465 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1465fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1465fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S1495fs frameshift loss of function - predicted APC S1495fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1495 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1495fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1495fs is predicted to reduce the ability of Apc to regulate beta-catenin.
S31fs frameshift loss of function - predicted APC S31fs results in a change in the amino acid sequence of the Apc protein beginning at aa 31 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of most known functional domains (UniProt.org), S31fs is predicted to result in a loss of Apc function.
T1301fs frameshift loss of function - predicted APC T1301fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1301 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1301fs has not been characterized, however Apc truncation mutants downstream of T1301 are inactivating (PMID: 18199528) thus, T1301fs is predicted to lead to a loss of Apc protein function.
T1438fs frameshift loss of function - predicted APC T1438fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1438 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1438fs has not been characterized, however Apc truncation mutants downstream of T1438 are inactivating (PMID: 18199528) thus, T1438fs is predicted to lead to a loss of Apc protein function.
T1445fs frameshift loss of function - predicted APC T1445fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1445 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1445fs has not been characterized, however Apc truncation mutants downstream of T1445 are inactivating (PMID: 18199528) thus, T1445fs is predicted to lead to a loss of Apc protein function.
T1459fs frameshift loss of function - predicted APC T1459fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1459 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1459fs has not been characterized, however Apc truncation mutants downstream of T1459 are inactivating (PMID: 18199528) thus, T1459fs is predicted to lead to a loss of Apc protein function.
T1487fs frameshift loss of function - predicted APC T1487fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1487 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1487fs has not been characterized, however, due to the effects of Apc truncation mutations downstream of T1487 (PMID: 10346819, PMID: 18199528), T1487fs is predicted to result in a loss in Apc protein function.
T1493fs frameshift loss of function - predicted APC T1493fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1493 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1493fs has not been characterized, however Apc truncation mutants downstream of T1493 are inactivating (PMID: 18199528) thus, T1493fs is predicted to lead to a loss of Apc protein function.
T1496fs frameshift loss of function - predicted APC T1496fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1496 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1496fs has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), T1496fs is predicted to reduce the ability of Apc to regulate beta-catenin.
T1556fs frameshift loss of function - predicted APC T1556fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1556 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1556fs has not been characterized, however Apc truncation mutants downstream of T1556 are inactivating (PMID: 18199528) thus, T1556fs is predicted to lead to a loss of Apc protein function.
V1377fs frameshift loss of function - predicted APC V1377fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1377 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). V1377fs has not been characterized, however, Apc truncation mutants downstream of V1377 are inactivating (PMID: 18199528) thus, V1377fs is predicted to lead to a loss of Apc protein function.
Y1376fs frameshift loss of function - predicted APC Y1376fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1376 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Y1376fs has not been characterized, however Apc truncation mutants downstream of Y1376 are inactivating (PMID: 18199528) thus, Y1376fs is predicted to lead to a loss of Apc protein function.