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Gene Symbol APC
Synonyms BTPS2 | DESMD | DP2 | DP2.5 | DP3 | GS | PPP1R46
Gene Description APC, adenomatous polyposis coli, is a tumor suppressor (PMID: 30562755) and multi-domain protein regulating numerous cellular functions through interaction with beta-catenin and subsequent inhibition of Wnt signalling (PMID: 10959075). APC germline mutations are associated with familial adenomatous polyposis (PMID: 30562755) and somatic mutations with colon, endometrial, NSCLC, and breast cancers (PMID: 27283171).
ACMG Incidental List v3.0:
Yes, Familial adenomatous polyposis (PMID: 34012068)
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
324 5 5q22.2 NM_000038 Tumor suppressor (PMID: 30606230)

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
A1296fs frameshift loss of function - predicted APC A1296fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1296 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1296fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1296 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1305fs frameshift loss of function - predicted APC A1305fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1305 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1305fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1305 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1316fs frameshift loss of function - predicted APC A1316fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1316 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1316fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1316 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1325fs frameshift loss of function - predicted APC A1325fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1325 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1325fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1325 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1351fs frameshift loss of function - predicted APC A1351fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1351 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1351fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1351 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1402fs frameshift loss of function - predicted APC A1402fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1402 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1402fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1402 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1446fs frameshift loss of function - predicted APC A1446fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1446 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1446fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1446 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1470fs frameshift loss of function - predicted APC A1470fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1470 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1470fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1470 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1471fs frameshift loss of function - predicted APC A1471fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1471 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1471fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1471 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1475fs frameshift loss of function - predicted APC A1475fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1475 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1475fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1475 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1485fs frameshift loss of function - predicted APC A1485fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1485 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1485fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1485 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A1492fs frameshift loss of function - predicted APC A1492fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1492 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1492fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1492 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
A928fs frameshift loss of function - predicted APC A928fs results in a change in the amino acid sequence of the Apc protein beginning at aa 928 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A928fs has not been characterized, however, due to the effects of other truncation mutations downstream of A928 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
C1274fs frameshift loss of function - predicted APC C1274fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1274 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1274fs has not been characterized, however, due to the effects of other truncation mutations downstream of C1274 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
C1289fs frameshift loss of function - predicted APC C1289fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1289 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1289fs has not been characterized, however, due to the effects of other truncation mutations downstream of C1289 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
C1387fs frameshift loss of function - predicted APC C1387fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1387 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1387fs has not been characterized, however, due to the effects of other truncation mutations downstream of C1387 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
C1578fs frameshift unknown APC C1578fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1578 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). C1578fs has been identified in sequencing studies (PMID: 20102718), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Feb 2024).
D1297fs frameshift loss of function - predicted APC D1297fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1297 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1297fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1297 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1318fs frameshift loss of function - predicted APC D1318fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1318 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1318fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1318 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1394fs frameshift loss of function - predicted APC D1394fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1394 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1394fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1394 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1422fs frameshift loss of function - predicted APC D1422fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1422 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1422fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1422 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1425fs frameshift loss of function - predicted APC D1425fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1425 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1425fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1425 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1484fs frameshift loss of function - predicted APC D1484fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1484 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1484fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1484 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1486fs frameshift loss of function - predicted APC D1486fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1486 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1486fs has not been characterized, however, due to the effects of other truncation mutations downstream of D1486 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
D1636fs frameshift unknown APC D1636fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1636 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D1636fs has been identified in sequencing studies (PMID: 36013219), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Feb 2024).
D962fs frameshift loss of function - predicted APC D962fs results in a change in the amino acid sequence of the Apc protein beginning at aa 962 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). D962fs has not been characterized, however, due to the effects of other truncation mutations downstream of D962 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1295fs frameshift loss of function - predicted APC E1295fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1295 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1295fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1295 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1306fs frameshift loss of function - predicted APC E1306fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1306 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1306fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1306 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1309fs frameshift loss of function - predicted APC E1309fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1309 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1309fs has not been characterized, however, based on the effects of a similar frameshift mutation at E1309 (PMID: 10213492, PMID: 17189293), is predicted to lead to a loss of Apc protein function.
E1464fs frameshift loss of function - predicted APC E1464fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1464 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1464fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1464 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1494fs frameshift loss of function - predicted APC E1494fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1494 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1494fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1494 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1536fs frameshift loss of function - predicted APC E1536fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1536 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1536fs has not been characterized however, due to the effects of other truncation mutations downstream of 1536 (PMID: 10346819), E1536fs is predicted to lead to a loss of Apc protein function.
E1550fs frameshift loss of function - predicted APC E1550fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1550 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1550fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1550 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E1554fs frameshift loss of function - predicted APC E1554fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1554 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E1554fs has not been characterized, however, due to the effects of other truncation mutations downstream of E1554 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
E582fs frameshift loss of function - predicted APC E582fs results in a change in the amino acid sequence of the Apc protein beginning at aa 582 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). E582fs has not been characterized, however, due to the effects of other truncation mutations downstream of E582 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
F1354fs frameshift loss of function - predicted APC F1354fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1354 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). F1354fs has not been characterized, however, due to the effects of other truncation mutations downstream of F1354 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
F1491fs frameshift loss of function - predicted APC F1491fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1491 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). F1491fs has not been characterized, however, due to the effects of other truncation mutations downstream of F1491 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
G1312fs frameshift loss of function - predicted APC G1312fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1312 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). G1312fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1312 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
G1357fs frameshift loss of function - predicted APC G1357fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1357 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). G1357fs has not been characterized, however, due to the effects of other truncation mutations downstream of G1357 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
H1375fs frameshift loss of function - predicted APC H1375fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1375 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). H1375fs has not been characterized, however, due to the effects of other truncation mutations downstream of H1375 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
H1490fs frameshift loss of function - predicted APC H1490fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1490 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). H1490fs has not been characterized, however, due to the effects of other truncation mutations downstream of H1490 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
I1164fs frameshift loss of function - predicted APC I1164fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1164 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1164fs has not been characterized, however, due to the effects of other truncation mutations downstream of I1164 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
I1307fs frameshift loss of function - predicted APC I1307fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1307 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1307fs has not been characterized, however, due to the effects of other truncation mutations downstream of I1307 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
I1311fs frameshift loss of function - predicted APC I1311fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1311 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1311fs has not been characterized, however, due to the effects of other truncation mutations downstream of I1311 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
I1557fs frameshift loss of function - predicted APC I1557fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1557 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I1557fs has not been characterized, however, due to the effects of other truncation mutations downstream of I1557 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
I606fs frameshift loss of function - predicted APC I606fs results in a change in the amino acid sequence of the Apc protein beginning at aa 606 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). I606fs has not been characterized, however, due to the effects of other truncation mutations downstream of I606 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
inact mut unknown loss of function APC inact mut indicates that this variant results in a loss of function of the Apc protein. However, the specific amino acid change has not been identified.
K1310fs frameshift loss of function - predicted APC K1310fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1310 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1310fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1310 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
K1437fs frameshift loss of function - predicted APC K1437fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1437 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1437fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1437 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
K1449fs frameshift loss of function - predicted APC K1449fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1449 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1449fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1449 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
K1462fs frameshift loss of function - predicted APC K1462fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1462 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1462fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1462 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
K1555fs frameshift loss of function - predicted APC K1555fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1555 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1555fs has not been characterized, however, due to the effects of other truncation mutations downstream of K1555 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
K1817fs frameshift unknown APC K1817fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1817 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1817fs has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, Feb 2024).
L1302fs frameshift loss of function - predicted APC L1302fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1302 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1302fs has not been characterized, however, due to the effects of truncation mutations downstream of L1302 (PMID: 10346819, PMID: 18199528), is predicted to lead to a loss of Apc protein function.
L1488fs frameshift loss of function - predicted APC L1488fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1488 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1488fs has not been characterized, however, due to the effects of other truncation mutations downstream of L1488 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
L1489fs frameshift loss of function - predicted APC L1489fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1489 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). L1489fs has not been characterized, however, due to the effects of other truncation mutations downstream of L1489 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
M1431fs frameshift loss of function - predicted APC M1431fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1431 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). M1431fs has not been characterized, however, due to the effects of other truncation mutations downstream of M1431 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
mutant unknown unknown APC mutant indicates an unspecified mutation in the APC gene.
N1300fs frameshift loss of function - predicted APC N1300fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1300 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1300fs has not been characterized, however, due to the effects of other truncation mutations downstream of N1300 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
N1455fs frameshift loss of function - predicted APC N1455fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1455 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1455fs has not been characterized, however, due to the effects of other truncation mutations downstream of N1455 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
N1819fs frameshift unknown APC N1819fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1819 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N1819fs has been identified in the scientific literature (PMID: 28179481), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Feb 2024).
N741fs frameshift loss of function - predicted APC N741fs results in a change in the amino acid sequence of the Apc protein beginning at aa 741 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N741fs has not been characterized, however, due to the effects of other truncation mutations downstream of N741 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
N869fs frameshift loss of function - predicted APC N869fs results in a change in the amino acid sequence of the Apc protein beginning at aa 869 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N869fs has not been characterized, however, due to the effects of other truncation mutations downstream of N869 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1319fs frameshift loss of function - predicted APC P1319fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1319 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1319fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1319 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1361fs frameshift loss of function - predicted APC P1361fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1361 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1361fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1361 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1372fs frameshift loss of function - predicted APC P1372fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1372 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1372fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1372 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1373fs frameshift loss of function - predicted APC P1373fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1373 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1373fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1373 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1439fs frameshift loss of function - predicted APC P1439fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1439 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1439fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1439 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1440fs frameshift loss of function - predicted APC P1440fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1440 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1440fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1440 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1443fs frameshift loss of function - predicted APC P1443fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1443 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1443fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1443 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1453fs frameshift loss of function - predicted APC P1453fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1453 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1453fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1453 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1458fs frameshift loss of function - predicted APC P1458fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1458 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1458fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1458 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1483fs frameshift loss of function - predicted APC P1483fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1483 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1483fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1483 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
P1497fs frameshift loss of function - predicted APC P1497fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1497 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). P1497fs has not been characterized, however, due to the effects of other truncation mutations downstream of P1497 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Q1294fs frameshift loss of function - predicted APC Q1294fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1294 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1294fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1294 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Q1303fs frameshift loss of function - predicted APC Q1303fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1303 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1303fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1303 (PMID: 18199528, PMID: 10346819), is predicted to lad to a loss of Apc protein function.
Q1378fs frameshift loss of function - predicted APC Q1378fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1378 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). APC Q1378fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1378 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Q1429fs frameshift loss of function - predicted APC Q1429fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1429 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Q1429fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q1429 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
R1314fs frameshift loss of function - predicted APC R1314fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1314 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). R1314fs has not been characterized, however, due to the effects of other truncation mutations downstream of R1314 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
R1348fs frameshift loss of function - predicted APC R1348fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1348 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). R1348fs has not been characterized, however, due to the effects of other truncation mutations downstream of R1348 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
R1435fs frameshift loss of function - predicted APC R1435fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1435 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). R1435fs has not been characterized, however, due to the effects of other truncation mutations downstream of R1435 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1315fs frameshift loss of function - predicted APC S1315fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1315 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1315fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1315 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1355fs frameshift loss of function - predicted APC S1355fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1355 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1355fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1355 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1356fs frameshift loss of function - predicted APC S1356fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1356 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1356fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1356 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1364fs frameshift loss of function - predicted APC S1364fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1364 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1364fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1364 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1411fs frameshift loss of function - predicted APC S1411fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1411 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1411fs has not been characterized, however, due to the effects of truncation mutations downstream of S1411 (PMID: 10346819, PMID: 18199528), is predicted to lead to a loss in Apc protein function.
S1436fs frameshift loss of function - predicted APC S1436fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1436 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1436fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1436 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1465fs frameshift loss of function - predicted APC S1465fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1465 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1465fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1465 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S1495fs frameshift loss of function - predicted APC S1495fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1495 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1495fs has not been characterized, however, due to the effects of other truncation mutations downstream of S1495 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
S31fs frameshift loss of function - predicted APC S31fs results in a change in the amino acid sequence of the Apc protein beginning at aa 31 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S31fs has not been characterized, however, due to the effects of other truncation mutations downstream of S31 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1301fs frameshift loss of function - predicted APC T1301fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1301 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1301fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1301 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1438fs frameshift loss of function - predicted APC T1438fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1438 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1438fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1438 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1445fs frameshift loss of function - predicted APC T1445fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1445 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1445fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1445 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1459fs frameshift loss of function - predicted APC T1459fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1459 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1459fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1459 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1487fs frameshift loss of function - predicted APC T1487fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1487 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1487fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1487 (PMID: 10346819, PMID: 18199528), is predicted to lead to a loss of Apc protein function.
T1493fs frameshift loss of function - predicted APC T1493fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1493 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1493fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1493 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1496fs frameshift loss of function - predicted APC T1496fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1496 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1496fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1496 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
T1556fs frameshift loss of function - predicted APC T1556fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1556 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1556fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1556 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
V1377fs frameshift loss of function - predicted APC V1377fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1377 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). V1377fs has not been characterized, however, due to the effects of other truncation mutations downstream of V1377 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
V1472fs frameshift loss of function - predicted APC V1472fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1472 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). V1472fs has not been characterized, however, due to the effects of other truncation mutations downstream of V1472 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Y1376fs frameshift loss of function - predicted APC Y1376fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1376 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Y1376fs has not been characterized, however, due to the effects of other truncation mutations downstream of Y1376 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Y935fs frameshift loss of function - predicted APC Y935fs results in a change in the amino acid sequence of the Apc protein beginning at aa 935 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). Y935fs has not been characterized, however, due to the effects of other truncation mutations downstream of Y935 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.