Gene Detail

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Gene Symbol APC
Synonyms BTPS2 | DESMD | DP2 | DP2.5 | DP3 | GS | PPP1R46
Gene Description APC, adenomatous polyposis coli, is a tumor suppressor (PMID: 30562755) and multi-domain protein regulating numerous cellular functions through interaction with beta-catenin and subsequent inhibition of Wnt signalling (PMID: 10959075). APC germline mutations are associated with familial adenomatous polyposis (PMID: 30562755) and somatic mutations with colon, endometrial, NSCLC, and breast cancers (PMID: 27283171).
ACMG Incidental List v2.0:
Yes, Adenomatous polyposis coli (PMID: 27854360)

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Molecular Profile Protein Effect Treatment Approaches
APC A1296fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1296V unknown
APC A1305fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1305G unknown
APC A1316fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1325fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1347T unknown
APC A1351fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1358E unknown
APC A1366V unknown
APC A1402fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1446fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1446_Q1447insDIA unknown
APC A1470fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1470T unknown
APC A1471fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1475fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1475V unknown
APC A1485fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1492fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1508V unknown
APC A1553T unknown
APC A1914* unknown
APC A214V unknown
APC A2690T unknown
APC A928fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A952Qfs*10 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1274fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1289fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1387* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1387fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1410* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1410S unknown
APC C1578fs unknown CTNNB1 Inhibitor Tankyrase Inhibitor
APC C207* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1003N unknown
APC D1022G unknown
APC D1058G unknown
APC D1083E unknown
APC D1297A unknown
APC D1297fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1318fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1394fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1422fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1422H unknown
APC D1422N unknown
APC D1425A unknown
APC D1425fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1484fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1486fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1566N unknown
APC D1636fs unknown
APC D2490N unknown
APC dec exp no effect
APC E1284K unknown
APC E1286G unknown
APC E1295* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E129Q unknown
APC E1306* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1306fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1306K unknown
APC E1309* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309Afs*3 loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309Dfs*4 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1317* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1317Q unknown
APC E1322* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1345* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1353* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1374* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1374K unknown
APC E1379* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1397* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1408* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1451* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1461* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1464* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1464fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1494fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1494K unknown
APC E1513* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1536fs loss of function - predicted
APC E1544* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1547* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1547K unknown
APC E1552* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1554* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1554fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1577* unknown CTNNB1 Inhibitor Tankyrase Inhibitor
APC E190* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E582fs loss of function - predicted CTNNB1 Inhibitor
APC E658* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E763* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E853* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E853* APC K1555*
APC E853* APC T1556fs
APC E868* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC F1354fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC F1491fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1120E no effect - predicted
APC G1312* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1312fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1312R unknown
APC G1339_S1340dup unknown
APC G1357fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1416* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1499* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1499R unknown
APC G2303R unknown
APC G2502S unknown
APC G471* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G471E unknown
APC H1375fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC H1490fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1164fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1307fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1307K unknown
APC I1307Kfs*14 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1311fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1417* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1557fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1574* loss of function - predicted
APC I1918V unknown
APC I1926M unknown
APC I606fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I880T unknown
APC inact mut loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1308* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1310* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1310fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1350* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1363Rfs*10 loss of function - predicted
APC K1370* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1449fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1454E no effect - predicted
APC K1462fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1555* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1555fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1817fs unknown CTNNB1 Inhibitor Tankyrase Inhibitor
APC K716* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1129S unknown
APC L1302fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488Ffs*26 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1489fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1564* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L2253I unknown
APC L2401P unknown
APC L508F unknown
APC L665* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L665* APC R1450*
APC L684* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L795Sfs*25 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L852* loss of function - predicted CTNNB1 Inhibitor
APC M1431fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC M1525Lfs*39 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC mutant unknown
APC N1026S loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC N1118D unknown
APC N1142Y unknown
APC N1300fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N1455fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N1455Ifs*18 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N1819fs unknown
APC N1819fs APC wild-type
APC N741fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N813S no effect - predicted
APC N869fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1076L unknown
APC P1319fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1361fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1372fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1373fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1420L unknown
APC P1432H unknown
APC P1439fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1440fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1443fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1443Lfs*30 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1453fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1453S unknown
APC P1458fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1483fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1497fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1613H unknown
APC P1613S unknown
APC P950Afs*13 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1067* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1096* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1096R unknown
APC Q1127* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1131* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1131* APC Q1303*
APC Q1291* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1294* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1294fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1303* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1303fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1338* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1367* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1378* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1378fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1406* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1429* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1429fs BRAF N581S ERBB2 L755S
APC Q1429fs loss of function - predicted
APC Q1429R unknown
APC Q1444* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1447* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1469* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1480* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1517* loss of function - predicted
APC Q424* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q886* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R106C unknown
APC R1114* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1158K unknown
APC R1171H unknown
APC R1314fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1348fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1399Ffs*9 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1435* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1435fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1450* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1835T unknown
APC R213* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R216* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R230C unknown
APC R232* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R2525C unknown
APC R2673G unknown
APC R2714C unknown
APC R283* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R302* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R374W unknown
APC R405* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R499* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R554* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R564* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R640G loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R805* loss of function - predicted
APC R805Q unknown
APC R876* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R876Q unknown
APC S1197* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1197* APC S1278*
APC S1215* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1215* APC S1278*
APC S1278* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S130G no effect - predicted
APC S1315* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1315fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1346* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1355fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1355P unknown
APC S1356* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1356fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1364fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1400* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1411fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1436fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1465fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1465Wfs*3 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1495fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1495I unknown
APC S2497L unknown
APC S2685G unknown
APC S31fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S590N unknown
APC S811* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S940L unknown
APC T1160K unknown
APC T1301fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1301Pfs*4 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1301S unknown
APC T1438fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1445fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1459fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1487fs loss of function - predicted
APC T1493fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1496fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1556fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1556Nfs*3 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T518A unknown
APC T621Lfs*9 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T683P unknown
APC V1352A unknown
APC V1377fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC V1452I unknown
APC V1472I unknown
APC V1804D unknown
APC V1822D unknown
APC V2112I unknown
APC W421* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC W553* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC W685R unknown
APC wild-type no effect
APC wild-type CTNNB1 wild-type
APC Y1376* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y1376fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y158H unknown
APC Y737* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y935* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor