Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol IL2RB
Synonyms CD122 | IL15RB | IMD63 | P70-75
Gene Description IL2RB, interleukin 2 receptor subunit beta, is a component of the high-affinity IL-2 receptor along with IL2RA and IL2RG (PMID: 23352221, PMID: 15933202), and the IL-15 receptor (PMID: 23352221, PMID: 32393513), and plays a role in regulating lymphocyte development (PMID: 8547641), T-cell activation and proliferation (PMID: 32393513, PMID: 7770771), and autoimmunity (PMID: 7770771). An IL2RB fusion with MYH9 has been reported in Ph-like acute lymphoblastic lymphoma (PMID: 25207766).
Additional content available in CKB BOOST