Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | ITK | ||||||||||
| Synonyms | EMT | LPFS1 | LYK | PSCTK2 | ||||||||||
| Gene Description | ITK, IL2 inducible T cell kinase, encodes an intracellular tyrosine kinase involved in T cell proliferation, differentiation, and function through activation of downstream signaling molecules in response to T cell receptor stimulation (PMID: 26936133, PMID: 28635957, PMID: 32049330). ITK inactivating mutations have been associated with susceptibility to Epstein-Barr virus-induced lymphoproliferative diseases, including Hodgkin’s lymphoma (PMID: 21109689, PMID: 21518255, PMID: 22289921, PMID: 25339095), and a fusion of ITK with SYK has been identified in peripheral T cell lymphoma (PMID: 16341044, PMID: 24076779). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
