Gene Detail

Gene Symbol JAK1
Synonyms JAK1A | JAK1B | JTK3
Gene Description JAK1, janus kinase 1, is a non-receptor protein tyrosine kinase involved in the interferon-alpha/beta/gamma pathway and is a member of the JAK/STAT signaling pathway (PMID: 15575979). JAK1 gain of function mutations have been identified in T-cell neoplasms (PMID: 30079384) and loss of function mutations are associated with high mutational burden and microsatellite instability (PMID: 29121062).
Entrez Id 3716
Chromosome 1
Map Location 1p31.3
Canonical Transcript NM_002227

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