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Gene Symbol JAK2
Synonyms JTK10 | THCYT3
Gene Description JAK2, tyrosine-protein kinase JAK2, is a non-receptor protein tyrosine kinase that binds cytokine receptors to activate the interferon-alpha/beta/gamma pathway and is a member of the JAK/STAT signaling pathway (PMID: 15575979, PMID: 30092288). JAK2 mutations are observed in a variety of tumor types, including myeloproliferative neoplasms (PMID: 30074114), lymphoma (PMID: 29984752), leukemia (PMID: 29979407), and cervical cancer (PMID: 30003068).

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Molecular Profile Protein Effect Treatment Approaches
JAK2 A660S unknown
JAK2 A676V unknown
JAK2 act mut gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 amp no effect
JAK2 C480F unknown
JAK2 C618R gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 D319G unknown
JAK2 D319N unknown
JAK2 D544G unknown
JAK2 D569Y unknown
JAK2 D620E unknown
JAK2 D873N gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 D894G unknown
JAK2 E1012* unknown
JAK2 E1080* unknown
JAK2 E10K unknown
JAK2 E177* loss of function - predicted
JAK2 E177V unknown
JAK2 E274* loss of function - predicted
JAK2 E283del unknown
JAK2 E386* loss of function - predicted
JAK2 E484K unknown
JAK2 E543_D544del unknown
JAK2 E61K unknown
JAK2 E818* loss of function - predicted
JAK2 E846D gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 E864K gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 V617F JAK2 E864K
JAK2 R683G JAK2 E864K
ETV6 - JAK2 JAK2 E864K
JAK2 E890* loss of function - predicted
JAK2 E985K unknown
JAK2 V617F JAK2 E985K
JAK2 E987D unknown
JAK2 V617F JAK2 E987D
JAK2 F1061W unknown
JAK2 V617F JAK2 Y931C JAK2 F1061W
JAK2 F439S unknown
JAK2 F537_K539delinsL gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556A gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556D gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556G gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556K gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556L unknown
JAK2 F556P gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556V gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556W no effect
JAK2 F560S unknown
JAK2 F694L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F694S gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 fusion unknown
JAK2 G127D unknown
JAK2 G276A unknown
JAK2 G295E unknown
JAK2 G301R unknown
JAK2 G417P gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 G417S unknown
JAK2 G48E unknown
JAK2 G571S no effect - predicted
JAK2 G614fs loss of function - predicted
JAK2 G831R unknown
ETV6 - JAK2 JAK2 G831R
JAK2 G834S unknown
JAK2 V617F JAK2 G935R
JAK2 G935R gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 R683G JAK2 G935R
ETV6 - JAK2 JAK2 G935R
JAK2 H110R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H538L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H538Q unknown
JAK2 H538_K539delinsL unknown
JAK2 H538_K539delinsQL gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H574R gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H587N unknown
JAK2 H606Q unknown
JAK2 H608Y unknown
JAK2 I1126V unknown
JAK2 I136L unknown
JAK2 I324T unknown
JAK2 I404N unknown
JAK2 I540N unknown
JAK2 I540T unknown
JAK2 I540_E543delinsMK unknown
JAK2 I645V unknown
JAK2 I682D gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682F gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682L no effect - predicted
JAK2 I682S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682T no effect - predicted
JAK2 I899T unknown
JAK2 I960V unknown
JAK2 V617F JAK2 I960V
JAK2 inact mut loss of function
JAK2 K167Q unknown
JAK2 K244R unknown
JAK2 K539I gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K539L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K607E gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K607N gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K882R loss of function
JAK2 K912T unknown
JAK2 L1047I unknown
JAK2 L113V unknown
JAK2 L359I unknown
JAK2 L393V gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 L545S unknown
JAK2 L579I unknown
JAK2 L579V unknown
JAK2 L583_A586delinsP unknown
JAK2 L583_A586delinsQ unknown
JAK2 L583_A586delinsS gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 L609fs loss of function - predicted
JAK2 L611fs loss of function - predicted
JAK2 L611S gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 L611V no effect - predicted
JAK2 L624P unknown
JAK2 L634P no effect - predicted
JAK2 L805V unknown
JAK2 L941F unknown
JAK2 L983F unknown
JAK2 V617F JAK2 L983F
JAK2 M483R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 M535I unknown
JAK2 M929I gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 V617F JAK2 M929I
ETV6 - JAK2 JAK2 M929I
JAK2 mutant unknown
JAK2 N1108S unknown
JAK2 N337D unknown
JAK2 N533I unknown
JAK2 N533Y unknown
JAK2 N542_E543del gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 N612fs loss of function - predicted
JAK2 N622I gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 N909K gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
ETV6 - JAK2 JAK2 N909K
JAK2 N99S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 over exp no effect
JAK2 over exp MPL over exp
JAK2 P1057S unknown
ETV6 - JAK2 JAK2 P1057S
JAK2 P58A gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 P870L unknown
JAK2 P870S unknown
JAK2 P933R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R1063H gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R1127K unknown
ETV6 - JAK2 JAK2 R1127K
JAK2 R133Q unknown
JAK2 R215Q unknown
JAK2 R277K gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R340Q no effect - predicted
JAK2 R426* loss of function - predicted
JAK2 R443* loss of function - predicted
JAK2 R487C unknown
JAK2 R541_E543delinsK unknown
JAK2 R564G unknown
JAK2 R564L unknown
JAK2 R564Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R588I unknown
JAK2 R588M unknown
JAK2 R683* loss of function - predicted
JAK2 R683E gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683G gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683H no effect - predicted
JAK2 R683K unknown
JAK2 R683S gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683T gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R867Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R938L unknown
JAK2 V617F JAK2 R938L
JAK2 R938Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R971G unknown
JAK2 V617F JAK2 R971G
JAK2 R975G gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
ETV6 - JAK2 JAK2 R975G
JAK2 rearrange unknown
JAK2 S1025C unknown
JAK2 V617F JAK2 Y931C JAK2 S1025C
JAK2 S126N unknown
JAK2 S15F unknown
JAK2 S358* loss of function - predicted
JAK2 S591L unknown
JAK2 S593C unknown
JAK2 S602I unknown
JAK2 S755R gain of function - predicted
JAK2 S797C unknown
JAK2 S887I unknown
JAK2 T108A gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 T246I unknown
JAK2 T514M unknown
JAK2 T875N gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V1075F unknown
JAK2 V617F JAK2 Y931C JAK2 V1075F
JAK2 V366G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V392M unknown
JAK2 V563I unknown
JAK2 V567A unknown
JAK2 V617F gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V617F JAK2 Y931C
JAK2 V617F MPL wild-type
DNMT3A S837* JAK2 V617F
JAK2 V617F JAK2 Y931C JAK2 Y1045W
JAK2 V617I gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V625F gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V881A gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
ETV6 - JAK2 JAK2 V881A
JAK2 V881fs loss of function - predicted
JAK2 V911A unknown
JAK2 W737L unknown
JAK2 wild-type no effect
CALR wild-type JAK2 wild-type MPL wild-type
JAK2 Y1007F loss of function
JAK2 Y1008F no effect
JAK2 Y1021F no effect
JAK2 Y1045F no effect
JAK2 Y1045W unknown
JAK2 Y1050F no effect
JAK2 Y1099F no effect
JAK2 Y254H unknown
JAK2 Y317H gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y44C gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y570E no effect
JAK2 Y570F no effect
JAK2 Y590E no effect
JAK2 Y590F no effect
JAK2 Y613E gain of function
JAK2 Y613F no effect
JAK2 Y613fs loss of function - predicted
JAK2 Y613_G614insTSY unknown
JAK2 Y62C unknown
JAK2 Y637C unknown
JAK2 Y637E no effect
JAK2 Y637F no effect
JAK2 Y766E loss of function - predicted
JAK2 Y766F no effect
JAK2 Y790E no effect
JAK2 Y790F no effect
JAK2 Y813D unknown
JAK2 Y813F no effect
JAK2 Y868F no effect
JAK2 Y913F no effect
JAK2 Y918F no effect
JAK2 Y918H unknown
ETV6 - JAK2 JAK2 Y918H
JAK2 Y931C gain of function JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 Y931F unknown JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y934F no effect
JAK2 Y940F no effect
JAK2 Y956F no effect
JAK2 Y966F no effect
JAK2 Y972F no effect