Gene Detail

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Gene Symbol KDR
Synonyms CD309 | FLK1 | VEGFR | VEGFR2
Gene Description KDR (VEGFR2), kinase insert domain receptor, is also known as vascular endothelial growth factor receptor 2 and is an endothelial cell surface receptor tyrosine kinase and member of the vascular endothelial growth factor family of proteins that plays a role in angiogenesis and cell proliferation through activation of RAF-MEK-MAP and PI3K-AKT pathways (PMID: 25568876, PMID: 29093528, PMID: 26578684). KDR amplification and overexpression have been reported in a variety of tumor types (PMID: 21382095, PMID: 27218826, PMID: 25231439, PMID: 20606037, PMID: 30819137) and somatic mutations have been reported in sarcomas and head and neck squamous cell carcinomas (PMID: 22314185, PMID: 11801954).

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Molecular Profile Protein Effect Treatment Approaches
KDR A1065T gain of function - predicted VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
KDR A248G unknown
KDR A331G unknown
KDR A352V unknown
KDR A467T unknown
KDR A532V unknown
KDR A904G unknown
KDR A973S unknown
KDR act mut gain of function VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
KDR amp no effect
ROS1 fusion KDR amp KIT amp PDGFRA amp
KDR C482R unknown
KDR C688F unknown
KDR C737Y unknown
KDR D1174Y unknown
KDR D1241G unknown
KDR D1241N unknown
KDR D1254N unknown
KDR D180E unknown
KDR D39Y unknown
KDR D558E unknown
KDR D639Y unknown
KDR D717V gain of function VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
KDR D832Y unknown
KDR D97N unknown
KDR D985N unknown
KDR D998N unknown
KDR E1114* unknown
KDR E1325* unknown
KDR E469K unknown
KDR E685K unknown
KDR E732K unknown
KDR E749K unknown
KDR E759V unknown
KDR F1115C unknown
KDR F921C unknown
KDR G1015D unknown
KDR G1145E unknown
KDR G1145R unknown
KDR G1304D unknown
KDR G1308* unknown
KDR G1308R unknown
KDR G394E unknown
KDR G394R unknown
KDR G509E unknown
KDR G509R unknown
KDR G539R gain of function - predicted
KDR G671R unknown
KDR G800D gain of function - predicted
KDR G800R gain of function - predicted
KDR G843D gain of function - predicted
KDR G846D unknown
KDR G873R unknown
KDR H1026N unknown
KDR H457Y unknown
KDR I1077L unknown
KDR I192F unknown
KDR I543F unknown
KDR K286N unknown
KDR K353N unknown
KDR K366T unknown
KDR L1049W unknown
KDR L1140M unknown
KDR L1156S unknown
KDR L1184F unknown
KDR L371fs unknown
KDR L462V unknown
KDR L840F unknown
KDR L889F unknown
KDR M1016K unknown
KDR M285I unknown
KDR mutant unknown
KDR over exp no effect
KDR P1147S unknown
KDR P1210L unknown
KDR P1210S unknown
KDR P1355del unknown
KDR P1355S unknown
KDR P32L unknown
KDR P359H unknown
KDR P421L unknown
KDR P453fs unknown
KDR P453L unknown
KDR P551S unknown
KDR positive unknown
KDR pos RET C634W
KDR Q37H unknown
KDR Q472H gain of function VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
KDR R1022Q gain of function - predicted
KDR R1032* unknown
KDR R1032Q unknown
KDR R1051W unknown
KDR R1118* unknown
KDR R1124I unknown
KDR R1124K unknown
KDR R1150I unknown
KDR R1229Q unknown
KDR R164I unknown
KDR R275* loss of function - predicted
KDR R275L unknown
KDR R347C unknown
KDR R347H unknown
KDR R57T unknown
KDR R73M unknown
KDR R787W unknown
KDR R791Q unknown
KDR R791W unknown
KDR R819* unknown
KDR R819Q unknown
KDR R929K unknown
KDR R932I unknown
KDR R944Q unknown
KDR R946C unknown
KDR R946H unknown
KDR R961W unknown
KDR R962H unknown
KDR S1021L unknown
KDR S1037L unknown
KDR S1100F unknown
KDR S1221N unknown
KDR S1231N unknown
KDR S265L unknown
KDR S26G unknown
KDR S338Y unknown
KDR S35I unknown
KDR S633F unknown
KDR S925F gain of function - predicted
KDR S984T unknown
KDR T1152M unknown
KDR T1258M unknown
KDR T1317I unknown
KDR T139N unknown
KDR T343M unknown
KDR T761M unknown
KDR T771M unknown
KDR T771R unknown
KDR V1041M unknown
KDR V159M unknown
KDR V218I unknown
KDR V254G unknown
KDR V297I unknown
KDR V476L unknown
KDR V547M unknown
KDR V655M unknown
KDR V769A unknown
KDR V805I unknown
KDR W1096* unknown
KDR W1096L unknown
KDR W1096R unknown
KDR W485* unknown
KDR W610* unknown
KDR wild-type no effect
KDR Y105C unknown
KDR Y365H unknown
KDR Y528S unknown
KDR Y822C unknown