Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol HES5
Synonyms bHLHb38
Gene Description HES5, hes family bHLH transcription factor 5, is a member of the basic helix-loop-helix transcriptional repressor family and is activated downstream of the NOTCH pathway to regulate cell differentiation (PMID: 27878283). Hypermethylation of the HES5 promoter has been observed early in prostate tumorogenesis (PMID: 25560400), while overexpression of HES5 has been demonstrated in NSCLC (PMID: 27878283) and has been associated with a 15-gene signature for prediction of colon cancer recurrence (PMID: 27998790).
Additional content available in CKB BOOST